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Journal of Korean Neurosurgical Society 1983;12(1): 71-81. |
| The Relationship Between Increased Intracranial Pressure and Central alpha-Adrenoceptors. |
| Sung Sin Doh, Hyoung Kun Kim, Kwang Yong Cho |
| Department of Neurosurgery, Chosun University, School of Medicine, Gwangju, Korea. |
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| ABSTRACT |
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The author attempted to clarify the nature of alpha-adrenoceptors in relation to the pressor response to the increased intracranial pressure(ICP) in urethane-anesthetized rabbits, using the epidural balloon method. 1) The blood pressure increased in parallel with the raised ICP which was made by gradual inflation of the balloon. 2) B-HT 920, an alpha2-agonist, which elicited depressor and bradycardiac responses in normal rabbits inhibited markedly the pressor response to the raised ICP.
3) Piperoxan, an alpha2-antagonist, potentiated the pressor response to the raised ICP. 4) Piperoxan antagonized the depressor and bradycardiac responses by B-HT 920 as well as the inhibitory effect of B-HT 920 on the pressor response to the raised ICP. 5) The pressor response to the raised ICP were not affected at all by prazosin, an alpha1-antagonist.
6) Neither the depressor and bradycardiac responses by B-HT 920 itself nor the inhibitory effect of B-HT 920 on the pressor response to the raised ICP were significantly affected by prazosin. It is inferred from these observations that the central alpha-adrenoceptors play an important role in producing the pressor response to the raised ICP and that the receptors involved here seems to be of alpha2-type. |
| Key Words:
Balloon method; B-HT 920; Piperoxan; Prazosin; alpha2-adrenoceptor |
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