Clinical Study on Mannitol Infusion on the Increased Intracranial Pressure Patients.

Han, Dae Hee

Original Article

Journal of Korean Neurosurgical Society 1976;5(2): 61-68.

Department of Neurosurgery, College of Medicine, Seoul National University, Seoul, Korea.

ABSTRACT

In order to study about the cause of deleterious effects of mannitol, which is frequently used in severe neurosurgical patients, author had performed a clinical experimental study after infusion of 15% mannitol intravenously. The amount of injection was 1.5 gm to 2.0 gm per kilogram, body weight. Twenty patients who were admitted to the Department of Neurosurgery, Seoul National University Hospital from April, 1976 to August, 1976, were studied. Author had observed changes of pulse rate and blood pressure, urine output and uring specific gravity at 15 minutes, 30 minutes, 45 minutes, 60 minutes, 120 minutes, 180 minutes, 240 minutes, 300 minutes and 360 minutes after completion of mannitol infusion. And author had studied those changes of CBC, electrolyte, serum and urine osmolalities. The results are as following : 1. Blood pressure was decreased 10mmHg in systolic pressure during 30 minutes to one hour after mannitol infusion but pulse rate was not significantly changed. 2. Urine output in 6 hours was 1368cc in average, of which 70 percent was excreted within three hours. 3. Changes of urine specific gravity were raising from one hour and peak value was at 5 hours after mannitol infusion. 4. Serum Na and urine osmolalities were significantly changed after mannitol infusion.