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Journal of Korean Neurosurgical Society 1990;19(3): 382-391.
Diffuse Axonal Injury : Changes of Cerebral Blood Flow, Intracranial Pressure and Evoked Potentials.
Chun Kun Park, Yung Kil Hong, Kyung Suck Cho, Min Woo Bail, Joon Ki Kang, Jun Un Song, Chang Rak Choi
Department of Neurosurgery, Catholic University College, Seoul, Korea.
Fifteen cases of diffuse axonal injury(DAI) brought about by nonmissile head injury in humans are analyzed. All cases were subjected to comprehensive clinical studies such as measurement of cerebral blood flow by SPECT, continuous intracranial pressure monitoring and multimodality evoked potentials(MEPs). In the patients with DAI, a high incidence of low cerebral perfusion and abnormal MEPs. especially auditory evoked potentials, were found, with high incidence of high velocity traffic accident injury mechanism. On the other hand, a low incidence of increased intracranial pressure was found and dehydrating agents such as glycerol and mannitol did not exert a beneficial influence upon the clinical courses or the outcomes. The outcome of the patients with DAI depended upon the duration of coma and whether or not brain stem signs were noted.
Key Words: Diffuse axonal injury; Shearing injury; Cerebral blood flow; Intracranial pressure; Evoked potentials
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