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Journal of Korean Neurosurgical Society 1994;23(4): 402-407.
Immunohistochemical Detection of p53 and c-fos in Brain Gliomas.
Eun Ik Son, Chang Chul Lee, Dong Won Kim, Man Bin Yim, In Hong Kim, Sang Sook Lee
1Department of Neurosurgery, Keimyung University School of Medicine, Taegu, Korea.
2Department of Pathology, Keimyung University School of Medicine, Taegu, Korea.
The epidemiology of cancer has long been suggested that cancer is multistep disease. We suspect some of these steps might be lated with activation of oncogenes and loss of tumor suppressor genes in primary brain tumors. Moreover, recent reports suggest that astrocytomas have shown alterations in chromosome 17p, and this chromosomal location that encodes the p53 protein, as well as c-fos gene may take an important role in the carcinogenesis of human primary brain tumors. Expression of p53 protein was detected in 12 of 17 cases(70.6%) of glioblastoma multiforme, 4 of 6 cases(66.6%) of anaplastic astrocytoma with positive nuclear p53 staining. All low grade astrocytomas and normal brain tissue failed to express p53. Correlation of p53 protein levels with mRNA alterations or genomic DNA alterations may help to guide future therapy or diagnosis of brain tumors. On the other hand, the level of c-fos oncoprotein expression may be correlated with the degree of cell differentiation and proliferation. The presence of these expression in low-grade astrocytoma suggest that activation of the c-fos gene is an early step in tumor development.
Key Words: Astrocytoma; Glioblastoma multiforme; Oncoprotein; C-fos; Mutant p53; Immunohistochemistry
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