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Journal of Korean Neurosurgical Society 1995;24(2): 189-194.
Expression of p53 Protein and PCNA in Brain Tumors.
Hong Soo Kim, Yeong Hwan Ahn, Eon Sub Park, Jin Ho Mok, Kwan Park, Young Baeg Kim, Byung Kook Min, Sung Nam Hwang, Jong Sik Suk, Duck Young Choi
1Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.
2Department of Pathology, College of Medicine, Chung-Ang University, Seoul, Korea.
Formalin-fixed, paraffin-embedded samples of 32 brain tumors(8 meningiomas, 10 astrocytomas(low grade 5, anaplastic 5), 8 glioblastoma multiforme, 6 oligodendrogliomas(low grade 2, anaplastic 3) were investigated by immunocytochemistry with monoclonal antibodies against p53 protein and proliferating cell nuclear antigen(PCNA). Expression of p53 protein was detected in 1 of 5 cases(20%) of low grade astrocytomas, 2 of 5 cases(40%) of anaplastic astrocytoma, 4 of 8 cases(50%) of glioblastoma multiforme and 4 of 4 cases(100%) of malignant oligodendroglioma. All low grade oligodendrogliomas, meningiomas fail to express p53. Expression of PCNA was detected in 3 of 8 cases of meningioma with very low labeling index(0-0.3), 2 of 5 cases of low grade astrocytoma with low labeling index(0-11.3), 3 of 5 cases of anaplastic astrocytoma with middle labeling index(0-28.2), 6 of 8 cases of glioblastoma multiforme and 4 of 4 cases of malignant oligodendroglioma with high labelling index(0-92.3, 7.6-48.1). Expression of PCNA was not detected in low grade oligodendrogliomas. Tumor group with high expression of p53 protein showed increment of PCNA expression. A strong positive correlation between tumor grade and extent of p53 protein and PCNA expression was found(p<0.002) .
Key Words: Brain tumor; P53 protein; PCNA; Immunochemistry; Labelling index
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