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Journal of Korean Neurosurgical Society > Volume 38(1); 2005 > Article
Journal of Korean Neurosurgical Society 2005;38(1): 65-67.
Intracranial Chloroma(Granulocytic Sarcoma) by Lymphocytic Leukemia.
Ho Seak Jeong, Moo Seong Kim, Yong Tae Jung, Jae Hong Sim
Department of Neurosurgery, Inje University Busan Paik Hospital, Busan, Korea. 667196@hanmail.net
ABSTRACT
Intracranial chloroma may occur in leukemia, although they are rare. A 23-year-old female complained diplopia. Brain magnetic resonance MR imaging showed tumors in the both cavernous sinus , both tentorial and anterior falx. Gamma-Knife radiosurgery was performed with maximal dose; 20Gy, marginal dose; 10Gy. Peripheral blood smear revealed leukemia, and bone marrow aspiration biopsy showed acute lymphocytic leukemia. Two weeks later, MR image for the stereotactic biopsy noticed markedly decreased tumor size. Biopsy result was lymphocytic leukemia. She received conventional radiation therapy, chemotherapy, and bone marrow transplantation. Brain involvement by acute lymphocytic leukemia is very rare. Even though chloroma are sensitive to radiation therapy, prognosis is poor because of the gravity of the underlying disease and association with impending blast transformation. The authors reports a intracranial chloroma by acute lymphocytic leukemia.
Key Words: Leukemia; Chloroma; Brain
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