Systematic Review and Meta-Analysis of Antibiotic-Impregnated Shunt Catheters on Anti-Infective Effect of Hydrocephalus Shunt
Article information
Abstract
Objective
Shunt infection is a common complication while treating hydrocephalus. The antibiotic-impregnated shunt catheter (AISC) was designed to reduce shunt infection rate. A meta-analysis was conducted to study the effectiveness of AISCs in reduction of shunt infection in terms of age, follow-up time and high-risk patient population.
Methods
This study reviewed literature from three databases including PubMed, EMBASE, and Cochrane Library (from 2000 to March 2019). Clinical studies from controlled trials for shunt operation were included in this analysis. A subgroup analysis was performed based on the patient’s age, follow-up time and high-risk population. The fixed effect in RevMan 5.3 software (Cochrane Collaboration) was used for this meta-analysis.
Results
This study included 19 controlled clinical trials including 10105 operations. The analysis demonstrated that AISC could reduce the infection rate in shunt surgery compared to standard shunt catheter (non-AISC) from 8.13% to 4.09% (odds ratio [OR], 0.48; 95% confidence interval [CI], 0.40–0.58; p=0.01; I2=46%). Subgroup analysis of different age groups showed that AISC had significant antimicrobial effects in all three groups (adult, infant, and adolescent). Follow-up time analysis showed that AISC was effective in preventing early shunt infections (within 6 months after implant). AISC is more effective in high-risk population (OR, 0.24; 95% CI, 0.14–0.40; p=0.60; I2=0%) than in general patient population.
Conclusion
The results of meta-analysis indicated that AISC is an effective method for reducing shunt infection. We recommend that AISC should be considered for use in infants and high-risk groups. For adult patients, the choice for AISC could be determined based on the treatment cost.
INTRODUCTION
Despite advances in catheter technology, shunt infection remains an issue of great concern for patients and surgeons. Patients who develop infection have a two-fold risk of mortality and a three-fold the time of shunt-related operations than those without infection. The reported prevalence of shunt infection varies from 1.5% to 69% [7,24]. In a recent multicenter study of 41 pediatric hospitals in the United States, the rate of cerebrospinal f luid shunt infection ranged from 4.1% to 20.5% [1]. Interestingly, Choux et al. [9] indicated that a 0% infection rate is not an impossible goal. Although the incidence of shunt infection has decreased in developed countries in recent years [8,15], infection remains a major cause of neurosurgical morbidity and mortality in developing countries.
Shunt infection is associated with lower IQ, poorer grades, increased seizure incidences, psychomotor retardation and decreased quality of life in children [19,39]. This also increases cost-related burden on the healthcare system and families. Coagulase-negative Staphylococcus is the main bacterial flora causing shunt infection because of its ability to form a biofilm on implanted materials. Staphylococcus aureus and Gram-negative bacilli are also common bacteria that cause shunt infection [38,40].
The control catheter in this study was made from silicone with no antimicrobial coating (non-antibiotic-impregnated shunt catheter, non-AISC). Recently, neurosurgeons have started using AISC in order to reduce the risk of shunt infection. The commonly used antimicrobial coating for shunt catheters contains 0.15% clindamycin and 0.054% rifampin [12]. The AISC system releases antibiotics to the catheter lumen and surrounding tissue at least 50 days after implantation [5,34]. A recent non-systematic review suggested that AISC reduces the risk of ventriculo-peritoneal shunt infections [17]. Konstantelias et al. [28] analyzed the effectiveness of antibiotic-impregnated coatings, silver-ion coatings and hydrogel coatings against infection. Thomas et al. [48] analyzed the effectiveness of AISCs in neonatal and adult patients. In conclusion, despite reports of effectiveness of these catheters, the published data for infection is not consistent. The meta-analysis of AISC infection with respect to follow-up time and high-risk patient population has not been systematically studied previously. Therefore, we report a comprehensive analysis of AISC effectiveness in this study.
MATERIALS AND METHODS
All randomized controlled trials were ethically approved. Based on the inclusion and exclusion criteria in this study, any research that conforms to the following criteria was included in the high-risk subgroup. 1) A priori as prematurity (<37 weeks gestational age), 2) shunts placed immediately postmeningitis, 3) conversion of external ventricular drains to shunt, 4) children with previous external ventricular drainage, and 5) frequent nosocomial infections. Shunting refers to ventriculoperitoneal, ventriculoatrial, ventriculopleural, lumboperitoneal, cystoperitoneal and subdural shunting. The antibiotics mainly used refer to 0.054% rifampicin and 0.15% clindamycin. The meta-analysis was performed and reported in accordance with Meta-analysis of Observational Studies in Epidemiology guidelines [47], the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement [31], and the guidelines of Cochrane Collaboration.
Search methods
PubMed (from 2000 to March 2019), EMBASE (from 2000 to March 2019), and the Cochrane Library (from 2000 to March 2019) were reviewed independently by two authors (W.X.Z. and Y.F.). PubMed was searched using the following terms—‘ventriculo-peritoneal shunt’ or ‘cerebrospinal fluid shunts’ and ‘infection’. EMBASE and Cochrane Library were searched using the following terms—‘cerebrospinal fluid shunting and infection’.
Study selection
The study had to meet the following inclusion criteria, 1) retrospective or prospective randomized controlled trials of AISC versus non-AISC in antimicrobial effects of hydrocephalus shunt, 2) language used is English, and was excluded if, 1) less than 10 cases, 2) no control group, 3) repetitive published study.
Data extraction
The extracted data included study design, geographic area, follow-up time, population characteristics and outcomes (infection, mortality). Information obtained from the studies was recorded in standard data collection form by author (W.X.Z.), and two other authors (Y.F. and Y.W.), who independently examined these articles. Differences of opinion were resolved through discussion.
Quality assessment
The quality of randomized and nonrandomized studies was independently determined using the Cochrane Handbook [21,46] by authors (W.X.Z. and Y.F.). Differences of opinion were resolved through discussions and consultation with two other authors (Y.W. and J.W.L.).
Data synthesis and statistical analysis
The RevMan 5.3 software of the Cochrane Collaboration was used for data analysis, using fixed effects model. The odds ratio (OR) and 95% confidence intervals (CIs) were calculated for all outcomes. Heterogeneity across studies was assessed based on a standard chi-squared test with significance being set at p<0.05 or I2 >50%. The extent of publication bias was estimated through visual inspection of funnel plot asymmetry.
RESULTS
Description of studies
It was initially determined to include 23 articles 2,3,11-13,16,18-20,22,23,25,26,29,30,32,33,35,39,41,42,45,50, and finally confirmed to 19 articles2,3,11-13,16,18,20,23,25,26,29,30,32,35,39,42,45,50, four of which were excluded (Fig. 1) 19,22,33,41. Details of the 19 studies included are in Table 1. The quality of the literatures were assessed in the Supplementary table 1 and 2
The 19 studies included two randomized controlled trials, and there was certain heterogeneity in the findings (p=0.02; I2=44%). Publication bias was detected (Fig. 2), which may be due to the tendency of researchers to publish superior results. However, we have not attempted to assess in detail since it was difficult to determine study quality in this area. No heterogeneity was found in the subgroup analysis.
Research data
A total of 19 studies were included in this meta-analysis. Data analysis showed that AISC had obvious advantages in terms of antimicrobial properties (OR, 0.48; 95% CI, 0.40–0.58; p<0.05; I2=46%; Fig. 3), however, the data was heterogeneous.
Age-based subgroup
This study divided patients into three groups based on patient age (Fig. 4), i.e., adult group (≥18 years), underage group (<18 years) and infant group (≤1 year). Eleven studies of underage patients showed significantly better results with AISC (OR, 0.57; 95% CI, 0.45–0.72; p=0.05; I2=45%), and the analysis was considerably significant (p<0.01). Overall, four of the 11 studies were investigated in both the underage and the infant group. This analysis showed that the use of AISC in infant group (OR, 0.42; 95% CI, 0.25–0.70; p=0.77; I2=0%; p<0.01) was better than that in the underage group. There were only three studies in the adult group, and the results clearly showed that the use of AISCs in adult patients was significantly better (OR, 0.21; 95% CI, 0.08–0.59; p=0.76; I2=0%; p<0.01) than that of the entire patient population. Results indicated that the antimicrobial effects of using AISC in adult group is superior to that in underage group, and the antimicrobial effect of using AISC in infant group was better than that in the underage group.
Follow-up schedule
The incidence of infection during different follow-up period was also analyzed (Fig. 5). We divided the follow-up time into three stages : 0–3 months, 4–6 months, and longer than 6 months. The infection was defined as early infection (0–6 months) and late infection (longer than 6 months) according to Sciubba et al. [44]. Our results showed that AISC has good antimicrobial effect (OR, 0.36; 95% CI, 0.19–0.73; p=0.25; I2=25%; p<0.01) in the 0–3 months follow-up period, the antimicrobial effects decreased with increase in follow-up time. We found that the antimicrobial effect was still strong at 3–6 months (OR, 0.55; 95% CI, 0.20–1.52; p=0.62; I2=0%; p=0.25). The antimicrobial effect of AISC was basically non-existent (OR, 0.80; 95% CI, 0.23–2.77; p= 0.48; I2=0%; p=0.75) at the end of 6 months after implantation. We did not observe any late shunt infection increase in AISC after 6 months of implantation (in the case of AISC group, 0–3 months infection rate : 4.27%, 3–6 months infection rate : 1.22%, longer than 6 months : 1.83%). This was consistent with other studies having a follow-up period longer than 6 months [2,16,39,42].
High-risk patients
The antimicrobial effectiveness of AISC in high-risk patients was analyzed (Fig. 6). The results of three studies indicated that the anti-infective effect of AISC in high-risk population (OR, 0.24; 95% CI, 0.14–0.40; p=0.60; I2=0%; p<0.01) was higher than that of the entire patient population group.
DISCUSSION
This meta-analysis analyzed the effectiveness of AISC in preventing shunt infection compared with that of non-AISC. In sensitivity analysis, heterogeneity was found to be caused by large samples.
A total of 19 studies were divided into three groups according to patient age. Our results showed that the antimicrobial effect of AISC was related to patient age. The most prominent antimicrobial effect was found in the adult group, and it was superior in the infant group compared to the underage group. This was consistent with the results of Konstantelias et al. [28]. In the Bayston study, the rate of infection for hydrocephalus shunting was higher in non-AISC subgroup amongst infants. The closer the age of the patient to the adult population, the lower the infection rate [4]. This is also consistent with our statistical results. This could be attributed to issues in the child’s immune system development, fragility of the skin and high density of skin bacteria [37]. Farber showed that AISC usage could reduce infection-related cost per patient [14]. However, in adults from lower socio-economic strata, non-AISC is an alternative, especially where there are fewer high-risk factors. Since the results analyzed showed that adult patients have low infection rate (5.8%) compared to those of other two groups (infant 9.66% and underage 8.40%), it is recommended to consider non-AISC implant to reduce the cost of treatment, unless high risk factors prevail.
The infection rate in 19 studies (divided into three groups) was analyzed based on the follow-up period. It can be seen that infection mainly occurred in the early stages of implantation and the late infection rate decreased with increase in follow-up time [10,27,36]. The study indicated consistency with previous reported results. Early infection may be caused by perioperative bacterial colonization on the shunt and acute immune reaction to implanted device, although the cause of late infection is clinically unclear [6,36,43,49]. The statistical results of non-AISC demonstrated that the infection rate was higher in the early stage of shunting (post implant 0–3 months), proving that antimicrobial effects of AISC was most required during this stage. Once the follow-up period exceeded 6 months, AISC tended to lose its antimicrobial function due to drug dilution, however, it did not lead to an increase in the incidence or toxicity of late period shunt infection. This research further indicated that the antimicrobial effects of AISC within 3–6 months of implantation got weaker compared to the first 0–3 months, and it totally lost antimicrobial function after 6 months.
Three studies were included in the analysis of anti-infective properties of AISCs in high-risk populations. AISC was obviously effective in the high-risk population. In high-risk patients, the use of AISC reduced the incidence of shunt infections from 13.16% for non-AISCs to 3.40%, which was consistent with the infection rate of 4.08% in the general population using AISC; the infection rate using non-AISC for the general population is 8.13%. There are several factors in highrisk groups, like coexisting symptoms, invasive surgeries, prolonged bed rest, inactivity, repeated exposure to bacterial environment in the hospital and other factors that can cause infection. Under these high-risk factors, the infection rate with the use of antimicrobial catheters had the same effect as with the use of antibiotics in the general population, which proved that antimicrobial catheters were most effective in high-risk populations. We recommend using antimicrobial catheters in high-risk populations.
Limitation
Most of the studies included in this meta-analysis are singlecenter, retrospective data with certain limitations. The present meta-analysis showed that AISC could reduce the incidence of complications associated with infection. However, large multicenter RCTS are still needed to further confirm this result.
CONCLUSION
Subgroup analysis of demonstrated patient age is an important factor associated with shunt infection, especially in infant population, that has a higher predilection for infections. The follow-up time analysis indicated that the antimicrobial effects should remain effective for at least 6 months in order to reduce the infection rate in the 3–6 months post-implantation period, which could be achieved by improving drug efficacy and coating technology. AISC is recommended for high-risk patients who are susceptible to infection. Non-AISCs may be considered for adult patients without high-risk infection factors, to reduce the cost of treatment. The revision of implanted shunt and hydrocephalus etiology are also significant factors accounting for patient infection, which are not included in this analysis and deserve further investigation in the future in terms of efficiency and safety.
Notes
CONFLICTS OF INTEREST
No potential conflict of interest relevant to this article was reported.
INFORMED CONSENT
This type of study does not require informed consent.
AUTHOR CONTRIBUTIONS
Conceptualization : HJZ, WBH, AHL
Data curation : WXZ, YF, YW, JWL
Formal analysis : CZ, YXY, STL, GL
Funding acquisition : HJZ
Methodology : WBH, WXZ
Project administration : HJZ, WBH
Visualization : WXZ, WBH
Writing - original draft : WXZ, WBH
Writing - review & editing : HJZ, WBH, WXZ
Supplementary Materials
The online-only data supplement is available with this article at https://doi.org/10.3340/jkns.2019.0219.