Metabolic Ratio of FDG-PET and Histologic Grading in Cerebral Gliomas.

Shin, Hyung Jin; Kim, Jong Hyun; Lee, Jung Il; Kim, Ki Joon; Cho, Tae Goo; Shin, Dong Ik; Kim, Jong Soo; Hong, Seung Chyul; Park, Kwan; Eoh, Whan; Kim, Sun Jung; Kim, Sang Eun; Suh, Yeon Lim

Original Article

Journal of Korean Neurosurgical Society 1997;26(4): 486-490.

Hyung Jin Shin, Jong Hyun Kim, Jung Il Lee, Ki Joon Kim, Tae Goo Cho, Dong Ik Shin, Jong Soo Kim, Seung Chyul Hong, Kwan Park, Whan Eoh, Sun Jung Kim, Sang Eun Kim, Yeon Lim Suh

¹Department of Neurosurgery, Sungkyunkwan University College of Medicine, Samsung Medical Center, Seoul, Korea.
²Department of Nuclear Medicine, Sungkyunkwan University College of Medicine, Samsung Medical Center, Seoul, Korea.
³Department of Diagnostic Pathology, Sungkyunkwan University College of Medicine, Samsung Medical Center, Seoul, Korea.

ABSTRACT

To assess the degree of malignancy in cerebral gliomas at the time of diagnosis, we compared the metabolic ratio using 18F-fluorodeoxyglucose(FDG)-Positron Emission Tomography(PET) with histologic grading and proliferative index(Ki-67) of cerebral gliomas. Materials for this study were histologically-examined 21 gliomas and they were divided into glioblastomas as group 1, anaplastic gliomas as group 2, and low-grade gliomas as group 3. The visual analysis of FDG-PET images showed hypermetabolic lesions in 14(87.5%) out of 16 high-grade gliomas (glioblastomas and anaplastic gliomas), and hypometabolic lesions in 4(80%) out of 5 low-grade gliomas. Tumor to cerebellum ratio(T/Cbll) in FDG-PET was used as metabolic ratio and the values of T/Cbll in each group were 1.30+/-0.10, 0.73+/-0.07, 0.70+/-0.07, respectively. In comparision of T/Cbll between group 1 with remaining two groups, differences were statistically significant(p=0.0002, p=0.0002, respectively), however, there was no statistical difference between group 2 and group 3. The values of Ki-67 were 24.16+/-5.66 in group 1, 8.10+/-2.70 in group 2, 5.46+/-1.23 in group 3, and differences were statistically significant between group 1 and group 2, 3(p=0.015, p=0.015, respectively), but there was no statistical difference between group 2 and group 3. The correlation between T/Cbll and Ki-67 was good and statistically significant(p=0.0047). In conclusion, the visual and semiquantitative analysis of FDG-PET would be helpful in determining the degree of malignancy in cerebral gliomas.

Key Words: Metabolic ratio; FDG-PET; Histologic grading; Proliferative index