Evaluation of Cerebrospinal Fluid Vascular Endothelial Growth Factor for the Brain Tumor.

Kim, Jong Hyun; Chung, Yong Gu; Lee, Hoon Kap; Lee, Ki Chan; Suh, Jung Keun

Original Article

Journal of Korean Neurosurgical Society 2003;33(2): 121-125.

Jong Hyun Kim, Yong Gu Chung, Hoon Kap Lee, Ki Chan Lee, Jung Keun Suh

Department of Neurosurgery, College of Medicine, Korea University, Seoul, Korea.

ABSTRACT

OBJECTIVE
Vascular endothelial growth factor(VEGF), which is also known as vascular permeability factor, induces angiogenesis and may play a key role in tumor-related neovascularization and peritumoral edema. There are many pathological conditions associated with VEGF expression, such as brain tumor, infection and trauma. Malignant brain tumor is characterized by its prominent neovascularization and severe peritumoral edema and it is known to express high VEGF activity. The aim of this study is to investigate any differences in cerebrospinal fluid(CSF) VEGF level among gliomas, and between tumors and non-tumorous conditions.
METHODS
Cerebrospinal fluid samples were collected from 28 patients whose diagnosis had been surgically proven and they were centrifuged and stored at -73 degrees C. The concentration of VEGF was analyzed using commercially available ELISA kit. RESULTS: Glioblastoma patients showed much higher level of CSF VEGF than those of other gliomas and non-tumorous conditions. And higher CSF VEGF level was found in invasive pituitary adenoma, recurrent oligoden-droglioma, central neurocytoma and diffuse axonal injury. CONCLUSION: Absolute CSF VEGF level can be useful biological marker for primary malignant glioma, especially glioblastoma, and serial check-ups may contribute to early diagnosis of malignant transformation of low grade astrocytoma.

Key Words: Brain tumor; CSF; VEGF; Tumor marker; Glioblastoma