The Outcome of Corpus Callosotomy for Intractable Epilepsy: 10 Years Experience of Corpus Callosotomy.

Seo, Jeong Suk; Lee, Jong Ju; Lee, Jung Kyo; Kang, Jung Gu; Lee, Sang Am; Ko, Tae Sung

Original Article

Journal of Korean Neurosurgical Society 2006;39(1): 16-19.

Jeong Suk Seo, Jong Ju Lee, Jung Kyo Lee, Jung Gu Kang, Sang Am Lee, Tae Sung Ko

¹Department of Neurological Surgery, Asan Medical Center College of Medicine, University of Ulsan, Seoul, Korea. jklee@amc.seoul.kr
²Department of Neurology, Asan Medical Center College of Medicine, University of Ulsan, Seoul, Korea.
³Department of Pediatrics, Asan Medical Center College of Medicine, University of Ulsan, Seoul, Korea.

ABSTRACT

OBJECTIVE
The purpose of this study is to evaluate the effect of the corpus callosotomy and to elucidate possible prognostic factors.
METHODS
The cases of 39 patients who underwent corpus callosotomy were reviewed retrospectively. Clinical outcomes were analyzed using Engel's classification, with consideration of various presurgical conditions and the extent of the callosal resection during follow-up more than one year.
RESULTS
Satisfactory outcome (Engel's class I, II) was obtained in 20 patients (51%) of 39 patients. In 36 cases with drop attack seizures, the class I, II outcomes were 22 patients (61%). When the patients were grouped according to the extent of callosal resection, the class I, II outcomes were 50% of the patients with anterior 1/2 or 2/3, 50% of those with anterior 4/5 callosotomy, and 57% of those with total callosotomy, respectively. The mean follow-up period was 34 months (24 to 58 months).
CONCLUSION
Although it is not statistically significant, the patients who had underwent total callosotomy show better outcomes than those with partial callosotomy. Corpus callosotomy is efficacious in controlling medically intractable epilepsy in appropriately selected patients.

Key Words: Intractable Epilepsy; Drop attack; Callosotomy