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Journal of Korean Neurosurgical Society > Volume 49(6); 2011 > Article
Journal of Korean Neurosurgical Society 2011;49(6): 323-328.
doi: https://doi.org/10.3340/jkns.2011.49.6.323
Effect of Amniotic Membrane to Reduce Postlaminectomy Epidural Adhesion on a Rat Model.
Hyu Jin Choi, Kyoung Beom Kim, Young Min Kwon
1Department of Neurosurgery, College of Medicine, Dong-A University, Busan, Korea. ymkwon@dau.ac.kr
2Department of Neurosurgery, The Grand Spine Hospital, Changwon, Korea.
ABSTRACT
OBJECTIVE:
Epidural fibrosis and adhesion are the main reasons for post-laminectomy sustained pain and functional disability. In this study, the authors investigate the effect of irradiated freeze-dried human amniotic membrane on reducing epidural adhesion after laminectomy on a rat model.
METHODS:
A total of 20 rats were divided into two groups. The group A did not receive human amniotic membrane implantation after laminectomy and group B underwent human amniotic membrane implantation after laminectomy. Gross and microscopic findings were evaluated and compared at postoperative 1, 3 and 8 weeks.
RESULTS:
The amount of scar tissue and tenacity were reduced grossly in group of rats with human amniotic membrane implantation (group B). On a microscopic evaluation, there were less inflammatory cell infiltration and fibroblast proliferation in group B.
CONCLUSION:
This experimental study shows that implantation of irradiated freeze-dried human amniotic membrane reduce epidural fibrosis and adhesion after spinal laminectomy in a rat model.
Key Words: Human amniotic membrane; Failed back surgery syndrome; Epidural adhesion; Laminectomy
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