| The Effect of Phosphodiesterase-4-Specific Inhibitor in the Rat Model of Spinal Nerve Ligation. |
| Sung Hoon Kim, Bit Na Ri Park, Seok Won Kim |
1Department of Rehabilitation, College of Medicine, Wonju Christian Hospital, Yonsei University, Wonju, Korea.
2Department of Neurosurgery, College of Medicine, Chosun University, Gwangju, Korea. ns64902@hanmail.net |
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| ABSTRACT |
OBJECTIVE
Peripheral neuropathy is characterized by hyperalgesia, spontaneous burning pain, and allodynia. The purpose of this study was to investigate the effect of rolipram, a phosphodiesterase-4-specific inhibitor, in a segmental spinal nerve ligation model in rats.
METHODS
Both the L5 and L6 spinal nerves of the left side of the rats were ligated. Phosphodiesterase-4 inhibitor (rolipram) and saline (vehicle) were administered intraperitoneally. We measured mechanical allodynia using von Frey filaments and a nerve conduction study.
RESULTS
The mechanical allodynia, which began to manifest on the first day, peaked within 2 days. Multiple intraperitoneal injections of rolipram ameliorated the mechanical allodynia. Furthermore, an intraperitoneal administration of rolipram improved the development of pain behavior and nerve conduction velocity.
CONCLUSION
This study suggests that the phosphodiesterase-4 inhibitor, rolipram, alleviates mechanical allodynia induced by segmental spinal nerve ligation in rats. This finding may have clinical implications. |
| Key Words:
Peripheral nerve injury; Allodynia; Rolipram |
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