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Journal of Korean Neurosurgical Society > Volume 63(1); 2020 > Article
Choi, Hyun, Kim, Jahng, and Kim: Radiographic and Clinical Outcomes Following Pedicle Subtraction Osteotomy : Minimum 2-Year Follow-Up Data

Abstract

Objective

The purpose of this study was to report the results of pedicle subtraction osteotomy (PSO) for fixed sagittal imbalance with a minimum 2-year follow-up. Besides, authors evaluated the effect of adjunctive multi-level posterior column osteotomy (PCO) on achievement of additional lumbar lordosis (LL) during PSO.

Methods

A total of 31 consecutive patients undergoing PSO for fixed sagittal imbalance were enrolled and analyzed. Correction angle of osteotomized vertebra (PSO angle) and other radiographic parameters including pelvic incidence (PI), thoracic kyphosis, LL, and sagittal vertical axis (SVA) were evaluated. Clinical outcomes and surgical complications were also assessed.

Results

The mean age was 66.0±9.3 years with a mean follow-up period of 33.2±10.5 months. The mean number of fused segments was 9.6±3.5. The mean operative time and surgical bleeding were 475.9±160.5 minutes and 1406.1±932.1 mL, respectively. The preoperative SRS-22 score was 2.3±0.7 and improved to 3.2±0.8 at the final follow-up. The mean PI was 54.5±9.5°. LL was changed from 7.0±28.9° to -50.2±13.2°. The PSO angle was 33.7±13.5° (15.6±20.1° preoperatively, -16.1±19.4° postoperatively). The difference of correction angle of LL (57.3°) was greater about 23.6° than which of PSO angle (33.7°). SVA was improved from 189.5±93.0 mm, preoperatively to 12.4±40.8 mm, postoperatively. There occurred six, eight, and 14 cases of complications at intraoperative, early (<2 weeks) postoperative, and late (≥2 weeks) postoperative period, respectively. Additional operations were needed in nine patients due to the complications.

Conclusion

PSO could provide satisfactory results for patients with fixed sagittal imbalance regarding clinical and radiographic outcomes. Additional correction of LL could be achieved with conduction of adjunctive multi-level PCOs during PSO.

INTRODUCTION

Patients with fixed sagittal malalignment are unable to stand erect without flexing their hips or knees due to the loss of segmental lumbar lordosis (LL) [5,26,27]. Disruption of normal sagittal alignment results in significant pain and disability, and associated with low health-related quality of life [13]. For patients with fixed sagittal imbalance who failed to conservative management, extensive spinal fusion with osteotomy is usually required [3,20,29]. Among those osteotomies, pedicle subtraction osteotomy (PSO) is the most widely performed one, especially in severe fixed sagittal imbalance [4,9,12].
According to the increasing incidence of adult spinal deformity with aging population as well as the understanding of the importance of sagittal alignment of the spine, the use of PSO has markedly expanded [25]. Gum et al. [14] reported the utilization of PSO procedure was increased by 3.2-fold within four years in the United States. In spite of the wide acceptance, the complication rate of PSO appears still higher than other spinal procedure [10,17,18,31].
The purpose of this study was to report the results of PSO for fixed sagittal imbalance with minimum 2-year follow-up. Besides, authors evaluated the effect of adjunctive multi-level PCO on achievement of additional LL during PSO.

MATERIALS AND METHODS

Demographic of patients

We obtained informed consent from all the patients and also approval from the Institutional Review Board of Seoul National University Bundang Hospital (approval No. B-1603/338-109). Consecutive adult patients (>18 year-old) who underwent PSO for fixed sagittal imbalance were sorted and analyzed from a single institutional database. All patients were operated by a single surgeon and observed for more than 2-year. Among total of 36 consecutive patients, five patients were excluded from this study because of the loss of follow-up or short of follow-up period (12.0-19.9 months of follow-up). Finally, 31 patients who underwent PSO between February 2012 and March 2016 were enrolled in this study. All patients suffered from persistent severe pain (visual analogue scale [VAS] ≥6), neurological deficit, or progressive deformity in spite of sufficient conservative treatment. Conservative treatment was comprised of physical therapy, medication, back muscle exercise, brace, and epidural steroid injection for more than three months. Decision for performing PSO was made for patients with type 2 sagittal imbalance (global sagittal imbalance) and lumbar curve without motion segment because of ankylosing spondylitis, severe degenerative change, or previous circumferential fusion along multiple vertebrae.

Radiographic assessment

Long-cassette (14×36 inch) anteroposterior and lateral standing plain radiographs obtained before surgery, immediately following surgery, and at the most recent follow-up were analyzed retrospectively. Sagittal vertical axis (SVA) was determined as the distance from the C7 sagittal plumb line to the perpendicular line drawn from the superior posterior corner of the S1 vertebral body. The thoracic kyphosis (TK) was measured between the lower endplates of T5 and T12. LL was measured between the upper endplate of L1 and S1. The angle at the PSO site was defined between the upper endplate of the adjacent upper vertebra and the lower endplate of the adjacent lower vertebra. Proximal junctional kyphosis (PJK) was defined as a proximal junctional angle of 10° greater than the preoperative value.

Clinical assessment

Clinical data including sex, age, and primary or revision surgery status were collected by medical chart review, retrospectively. Operative details such as the level of osteotomy, number of fused segment, operation time, estimated blood loss (EBL), transfused volume of red blood cell (RBC), and length of hospital stay were obtained. Complications were evaluated and divided into three groups regarding time of onset; intraoperative, early-postoperative (<2 weeks), and late-onset (≥2 weeks). Clinical outcomes were assessed by Scoliosis Research Society-22 (SRS-22) questionnaire, prior to operation and at the ultimate follow-up (at least 2-year after operation). Patient questionnaire was filled out by every patient themselves. Then, physical assistant registered the data into the database immediately after the completion of the survey.

Surgical procedure

The patients were positioned prone on the radiolucent operative table with chest bolster and pelvic girdles (Jackson table), to achieve maximal lordotic curvature and to avoid abdominal pressure. Intraoperative neurophysiological monitoring using somatosensory and motor evoked potentials was applied to every patient. Intraoperative administration of tranexamic acid and installation of cell salvage system were done in order to reduce surgical bleeding and RBC transfusion. Subperiosteal dissection was performed to expose bony structure as far as the tip of transverse process. Placement of pedicle screws with or without pelvic screws (S2 alar-iliac screws) was performed using freehand technique [8]. Multi-level posterior column osteotomies (PCO) as a Ponte procedure were performed at every lumbar vertebra.
Removal of all posterior elements is conducted at the PSO segment including the spinous process, lamina, and the superior and inferior articular processes adjacent to the pedicle. In addition, cephalad and caudal laminae were undercut to avoid dural buckling or neural impingement during closure of posterior column. Following cutting of proximal junction of transverse processes bilaterally, lateral surface of the vertebral body was carefully dissected while protecting segmental vessels. Next, pediculectomy and wedge-shaped cancellous bone removal were done. Usually, a temporary rod was placed across the osteotomy site to prevent subluxation or premature closure. Lateral cortex was removed with wedge-shaped, and remnant posterior cortex was depressed and fractured with downward cutting curette. Consequently, pedicle subtraction was accomplished with downward force by an operator and secured with multiple rod construct. After completing the fixation procedure, autografts and allografts were placed over the laminae, facet joints and transverse processes.

Statistical analysis

Statistical analysis was performed using IBM SPSS version 22.0 software for Windows (IBM, Corp., Armonk, NY, USA). The distributions of the variables were demonstrated as the mean value and standard deviation. Paired t-test was used to analyze the paired variables before and after osteotomy. Statistical significance was set at p<0.05.

RESULTS

Patients demographics

The patients included in this study were 27 females and four males, with a mean age of 66.0±9.3 years (Table 1). A mean follow-up period was 33.2±10.5 months. In terms of diagnosis, there were 16 cases of degenerative lumbar flatback, 11 cases of postoperative flatback, two cases of posttraumatic kyphosis, and two cases of tuberculous kyphosis. 64.5% (20/31) of patients had prior spinal surgeries, with a mean number of 1.2±1.2.

Operative and clinical outcomes

Operative details are summarized in Table 2. The most common level of osteotomy was L3 (15 cases), followed by L4 (eight cases), L1 (four cases), L2 (two cases), and T12 (two cases). The mean number of fused segments was 9.6±3.5. Pelvic fixation, by means of S2 alar-iliac screws, was conducted in 27 patients, and 19 patients received anterior column support by transforaminal lumbar interbody fusion at least one level. The mean operative time was 475.9±160.5 minutes. The amount of surgical bleeding was 1406.1±932.1 mL, and the volume of transfused RBC was 1063.0±568.1 mL. The length of hospital stay was 13.0±5.8 days. The preoperative SRS-22 score was 2.3±0.7, which improved to 3.2±0.8 at the final follow-up (p=0.000). All subscales in SRS-22 were significantly improved at the final follow-up, compared to those of preoperative value. The score of satisfaction with management was 3.7±0.9 (Table 3).

Radiographic outcomes

The mean pelvic incidence was 54.5±9.5° (Table 4). TK preoperatively and postoperatively was 16.2±18.5° and 27.0±12.8°, respectively. LL was changed from 7.0±28.9° to -50.2±13.2°. The correction angle of LL was 57.3±25.6° and sustained until last follow-up (loss of correction of 2.9±6.1°). The osteotomized vertebral angle was changed from 15.6±20.1° preoperatively to-16.1±19.4° postoperatively. The angle of correction in osteotomized vertebra (PSO angle) was 33.7±13.5°. The difference of correction angle between LL and PSO segment was 23.6°. The preoperative SVA was 189.5±93.0 mm, where the postoperative value was decreased to 12.4±40.8 mm. The loss of correction of SVA was 32.8±40.7 mm (last SVA of 44.8±48.2 mm).

Complications

Twenty out of 31 patients suffered from 28 complications (Table 5). Thus, the rate of total complications was 90.3% (28/31). Six cases of complications were occurred intraoperatively. Dural tear was most common (four cases), followed by screw malposition and chin sore (one case each).
There were eight complications during early postoperative period (<2 weeks). There were two cases of postoperative motor deficit, which required revision surgery in one patient. One patient suffered from postoperative voiding difficulty which required continuous intermittent catheterization. One patient suffered from postoperative wound dehiscence, and underwent revision surgery with local flap. Other complications were urinary tract infection, hydronephrosis, atrial fibrillation, and pulmonary effusion.
Late postoperative period complications (≥2 weeks) were identified in 14 cases. There were eight cases of PJK, one of which required revision surgery. There were four cases of rod fracture which required additional surgeries. Screw loosening was identified on routine follow-up in two patients with close observation. Additional operations were necessary in nine cases as a consequence of such complications.

DISCUSSION

In this study, we evaluated the radiographic and clinical outcomes following PSO, with a minimum 2-year follow-up. PSO showed strong effect for correction of the segmental angle of osteotomized vertebra (33.7±13.5°). Regarding sagittal imbalance, this study revealed significant improvement of SVA following PSO (from 189.5±93.0 mm preoperatively to 12.4±40.8 mm postoperatively). Radiographic outcomes including the PSO angle and improvement of sagittal malalignment were comparable to previous studies [5,12,15,19].
It is noteworthy that the correction of LL (57.3°) is quite greater compared to earlier reports. According to the most literatures previously published, the correction amount of LL is approximately 30°, which is nearly similar with the PSO angle [5,15,19,24,28]. That reflects most amount of LL correction was achieved within the PSO segment. On the other hand, in one study, the correction amount of LL was only 13°, whereas PSO angle was 27.2°, which is on the contrary to the present study. Authors concluded that compensatory low-LL was reduced as a response of corrected local mid-LL following thoracic PSOs in some patients [12].
In this study, authors corrected additional angle of 23.6° regarding LL (57.3°) over the angle of correction at PSO segment (33.7°). Authors think that performance of multi-level PCO (Ponte procedure) at every lumbar vertebra was attributed to gain additional LL (Fig. 1). Recently, multi-level PCO was reported as effective as PSO per se, and regarded as a viable option for the correction of rigid adult spinal deformity [16]. We think performing additional multi-level PCO during PSO would be beneficial to achieve more suitable LL. Whereas, in some patients with already fused lumbar spine due to previous surgery, the role of additional PCO may be limited because the PCO is on the premise of existence of mobile segment (Fig. 2).
The perioperative data is mostly comparable to previous studies such as surgical time, number of fused segment, and length of hospital stay. In earlier study, Bridwell et al. [5] reported the mean surgical time of 730 minutes. Recent literatures reported generally more reduced surgical time (336-438 minutes) [10,12,15], which is similar to our study (491 minutes). Regarding EBL, present study showed noticeably less EBL (1428 mL) compared to other studies (2371-5800 mL) [5,10,12,15,33]. Possible explanation of reduced EBL in current study is various blood conservation strategies in our institution including prompt bleeding control of decorticated bone and epidural space, intraoperative tranexamic acid infusion, and packing of gauze soaked with hemostatic agent to exposed surgical field [7].
The clinical outcome was favorable following PSO, which is concordant with the previous studies [2,33]. Although the assessment methods of clinical outcome were various among studies, most studies reported significant improvement of clinical outcome following PSO. It is noteworthy that the subscale of self-image was improved the most, whereas functional category the least, in the present study. These findings are also consistent with most previous literatures [11,22,23], possibly reflecting the double sidedness of the deformity correction surgery including long level instrumentation.
PSO is technically demanding procedure and associated with substantial rates of complications compared to other spinal procedures [2,15,30]. In our study, the prevalence of intraoperative complications (19.4%) and early post-operative complications (25.8%) was comparable to previous studies [1,19,23,24]. Daubs et al. [10] thoroughly evaluated perioperative (within 3-month) complications of PSO in 65 patients, and demonstrated intraoperative complication rates of 23% and total postoperative complication rates of 52.3%. They reported dural tear was the most common intraoperative complications (18.4%), which was comparable to the current study (12.9%).
One of the most serious complications during early postoperative period is neurological deteriorations following PSO. In the present study, postoperative neurological deficits were identified in three patients (two patients with transient motor weakness, one patient with permanent voiding difficulty) with the prevalence of 9.7% (3/31). Buchowski et al. [6] reported the intraoperative and postoperative deficits were seen in 11.1% of patients who underwent PSO (12/108). More recently, Eskilsson et al. [12] and Daubs et al. [10] reported the prevalence of neurological complications was 11% (12/104), and 6.2% (4/65), respectively. Generally, the prevalence of neurological complication in the present study was similar to other studies [23,24].
Majority of late-onset complications are associated with junctional kyphosis (with or without junctional failure) and pseudarthrosis presenting with instrument failure or loss of sagittal balance. There were fourteen cases of late-onset complications, including eight cases of PJK (25.8%). The rates of PJK reported quiet vary, however, most literatures report a rate of 20% to 40% [17,21,24,32]. Although longer period of followup is needed, our results regarding PJK were comparable to previous reports. There were six patients suggesting pseudarthrosis (19.4%), including four cases of rod fracture and two cases screw loosening. The rate of pseuarthrosis was comparable to the results by Yang et al. [33], however, additional period of follow-up is necessary since the pseudarthrosis is known to occur even after 2 years postoperatively [23].
This study was limited by the retrospective design with analysis of medical and radiographic records. Moreover, relatively small number of patients enrolled with short-term duration of follow-up may weaken the validity of this study. Despite those weaknesses, however, the radiographic outcomes and complication rates were mostly comparable to previous studies with relatively large sample size, which would assure the relevance of the present study. The unique point of the current study is the performance of adjunctive multi-level PCO in addition to PSO, which achieved greater correction angle of LL compared to the PSO angle.

CONCLUSION

PSO could provide satisfactory results for patients with fixed sagittal imbalance regarding clinical and radiographic outcomes. Complication rates were comparable to previous studies, however, longer period of follow-up would be needed to evaluate late-onset complications such as PJK and pseudarthrosis. Additional correction of LL could be achieved with conduction of adjunctive multi-level PCO during PSO.

Notes

No potential conflict of interest relevant to this article was reported.

INFORMED CONSENT

Informed consent was obtained from all individual participants included in this study.

AUTHOR CONTRIBUTIONS

Conceptualization : SJH

Data curation : HYC

Formal analysis : HYC

Methodology : SJH

Project administration : HYC

Visualization : HYC

Writing - original draft : HYC

Writing - review & editing : SJH, KJK, TAJ, HJK

Fig. 1.
A 77-year old female patient presenting with stooped posture and pain on her back and lower extremities. A : Preoperative sagittal whole spine X-ray showed sagittal imbalance with lumbar kyphosis. PSO with posterior instrumented fusion from T10 to pelvis was done. B : Sagittal balance was improved at final follow-up. Owing to multiple posterior column osteotomies in addition to PSO, the correction amount of lumbar lordosis (70.2°) is far greater than that of PSO angle (41.7°). PI : pelvic incidence, TK : thoracic kyphosis, LL : lumbar lordosis, SVA : sagittal vertical axis, PSO : pedicle subtraction osteotomy
jkns-2018-0170f1.jpg
Fig. 2.
A 71-year-old female patient presenting with stooped posture and pain on her back and lower extremities. She underwent prior lumbar spine surgeries at another hospital. A : Preoperative sagittal whole spine X-ray showed spinal instrumentation from L1 to L5 with bone cement materials at multiple levels. L4 PSO with posterior instrumented fusion from T9 to pelvis, and prophylactic vertebroplasties at T8 and T9 were done. B : Because of nearly fused posterior element of the lumbar spine, the correction amount of lumbar lordosis (36.5°) is almost same with PSO angle (34.8°). PI : pelvic incidence, TK : thoracic kyphosis, LL : lumbar lordosis, SVA : sagittal vertical axis, PSO : pedicle subtraction osteotomy.
jkns-2018-0170f2.jpg
Table 1.
Demographic data
Variable Value
Age (years) 66.0±9.3
Male : female 4 : 27
Etiology of deformity
 Degenerative lumbar flatback 16
 Postoperative flatback 11
 Posttraumatic kyphosis 2
 Tuberculous kyphosis 2
Prior operation
 Number of times 1.2±1.2
 Number of patients 20/31 (64.5%)
Table 2.
Operative characteristics
Variable Value
Number of fused segment 9.6±3.5
Surgical time (minutes) 475.9±160.5
Estimated blood loss (mL) 1406.1±932.1
Volume of transfused RBC (mL) 1063.0±568.1
Length of hospital stay (days) 13.0±5.8

Values are presented as mean±standard deviation. RBC : red blood cell

Table 3.
Clinical outcomes
Variable Preoperative Final p-value
SRS-22 2.3±0.7 3.2±0.8 0.000
 Function 2.4±0.9 2.9±0.9 0.019
 Pain 2.5±0.9 3.3±1.0 0.001
 Self-image 1.9±0.6 3.2±0.9 0.000
 Mental health 2.6±0.9 3.2±0.9 0.022
 Satisfaction with management 3.7±0.9

SRS-22 : Scoliosis Research Society-22 score

Table 4.
Radiographic data
Variable Value
Pelvic incidence (°) 54.5±9.5
Thoracic kyphosis (°)
 Preoperative 16.2±18.5
 Postoperative 27.0±12.8
 Ultimate follow-up 33.6±15.2
 Correction angle 10.8±11.9
 Loss of correction angle 7.1±10.1
Lumbar lordosis (°)
 Preoperative 7.0±28.9
 Postoperative -50.2±13.2
 Ultimate follow-up -46.7±13.1
 Correction angle -57.3±25.6
 Loss of correction angle 2.9±6.1
Sagittal vertical axis (mm)
 Preoperative 189.5±93.0
 Postoperative 12.4±40.8
 Ultimate follow-up 44.8±48.2
 Correction length -177.1±83.0
 Loss of correction length 32.8±40.7
Angle at the PSO site (°)
 Preoperative 15.6±20.1
 Postoperative -18.0±17.8
 Ultimate follow-up -16.1±19.4
 Correction angle -33.7±13.5
 Loss of correction angle 1.9±10.8

Values are presented as mean±standard deviation. PSO : pedicle subtraction osteotomy

Table 5.
Summary of complications
Type Number Additional surgery
Intraoperative
 Dural tear 4 1
 Screw malposition 1 1
 Chin sore 1
Perioperative (<2 weeks)
 Motor weakness 2 1
 Voiding difficulty 1
 Wound dehiscence 1 1
 Urinary tract infection 1
 Hydronephrosis 1
 Atrial fibrillation 1
 Pulmonary effusion 1
Late-onset (≥2 weeks)
 Proximal junctional failure 8 1
 Rod fracture 4 4
 Screw loosening 2
Total 28 (in 20 patients) 9 (in 9 patients)

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