A Histochemical Study on the Neutrophil Alkaline Phosphatase Activity of Peripheral Blood and Cerebrospinal Fluid in the Patients with Spontoneous Subarachnoid Hemorrhage.

Park, Youn Kyu

Original Article

Journal of Korean Neurosurgical Society 1975;4(2): 269-276.

Youn Kyu Park

Department of Neurosurgery, Busan National University, School of Medicine, Busan, Korea.

ABSTRACT

There have been many studies on the neutrophil alkaline phosphatase(abbreviated as NAP) activity in the patients with various internal disease, and various enzymes and electrolytes in the patients with the disease of central nervous system including subarachnoid hemorrhage. It is rare that the NAP activity is the subject of study on the patients with spontaneous subarachnoid hemorrhage, so the author investigated the NAP activities of peripheral blood and cerebrospinal fluid, with naphthol AS-MX phosphate method in 36 patients with spontaneous subarachnoid hemorrhage who were admitted to Dept. of Neurosurgery, Busan National University Hospital, from Jan. 1975 to Aug. 1975. The author obtained following results: 1. The NAP activity of peripheral blood in the patients with spontaneous subarachnoid hemorrhage was more active than in the normal individuals. 2. The NAP activity of peripheral blood and cerebrospinal fluid did not correlate with the neutrophilia in the patients with spontaneous subarachnoid hemorrhage. 3. In the patients with spontaneous subarachnoid hemorrhage the NAP activity of peripheral blood did not correlate with the NAP activity of cerebrospinal fluid. 4. The NAP activity of cerebrospinal fluid correlated with the consciousness, but the NAP activity of peripheral blood did not.