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Journal of Korean Neurosurgical Society > Volume 12(4); 1983 > Article
Journal of Korean Neurosurgical Society 1983;12(4): 641-647.
The Effect of Naloxone for the C.N.S. Lesion.
Young Soo Kim, Sun Ho Kim, Jung Uhn Choi, Sang Sup Chung, Kyu Chang Lee
Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
Naloxone, specific opiate antagonist, selectively elevates plasma dopamine level, with the dopamine changes significantly correlated with improved cardiovascular function and reduces the release of endorphin in the endorphin stress system. As the results, naloxone increases both, systemic blood pressure and regional blood flow, limiting secondary ischemic changes and improving neurological function in the C.N.S. lesion by the experimental studies. We have studied the clinical effects of naloxone on the 40 cases of C.N.S. lesions from April to October, 1983. We have discussed our results and reviewed literatures.
Key Words: Naloxone; Endorphin; Ischemia
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