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Journal of Korean Neurosurgical Society 1984;13(2): 217-226.
Effects of Diphenylhydantoin on CBF, CMRO2, CMRG, and SEP in Experimental Cerebral Ischemia.
Jong Oh Lee, Hoon Kap Lee
Department of Neurosurgery, College of Medicine, Korea University, Seoul, Korea.
Phenytoin(DPH) has been reported to be a benefit in the cerebral ischemia. To study the effect of DPH in an experimental stroke model. We subjected 45 cats to middle cerebral artery(MCA) occlusion 4 hrs after the placement of a MCA clip by a retro-orbital approach. Infarct size was determined 2 days after MCA occlusion. 20 animals served as control and received saline 2 ml bolus. All of these animal observed 1 hour, 1 day and 2 days after the removal of clip. In 20 treated animals, DPH was administered 50 mg/kg bolus every 6 hours intravenously after removal of clip. Infarct size was not significantly different between the control and treated groups. However, in DPH treated group, CBF, CMRO2, CMRG SEP were improved in early stage of ischemia.
Key Words: Cerebral ischemia; Diphenylhydantoin
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