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Journal of Korean Neurosurgical Society 1988;17(4): 613-624. |
| Ultrastructural Changes in the Feline Basilar Artery following Experimental Subarachnoid Hemorrhage. |
| Byung Kook Min, Young Baeg Kim, Sung Nam Hwang, Jong Sik Suk, Duck Young Choi, Kwang She Rhim |
| Department of Neurosurgery, College of Medicine, Chung Ang University, Seoul, Korea. |
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| ABSTRACT |
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Experimental subarachnoid hemorrhage(SAH) was produced in adult cats by injection of autologous blood(6ml) into prepontine cistern by tranclival approach and cisterna magna. The animals were sacrificed 1, 3, 5, 7 or 14 days later and basilar artery segments were prepared for electron microscopy. The following observations were made: 1) 1 to 7 days after SAH, electron micrograph showed round-shaped endothelial cells in tunica intima and disappearance of zonular occludens. Endothelial detachment from internal elastic membrane and intracytoplasmic vacuolation of endothelial cells as well as destruction of mitochondrial cirstae in tunica media. 2) 14 days after SAH, electron micrograph showed the normal findings in tunica intima and tunica media of the vessel walls. On the basis of the above findings, I found that the ultrastructural changes in the basilar arterial wall, which had presumably developed as a consequence of experimental SAH were reversible. |
| Key Words:
Experimental subarachnoid hemorrhage; Transclival approach |
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