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Journal of Korean Neurosurgical Society 1988;17(5): 1029-1034.
Diagnosis of Cerebrovascular Disease Using 99mTc-HMPAO SPECT.
Do Heum Yoon, Seung Kon Huh, Kyu Chang Lee, Do Yun Lee, Tae Sub Chung
1Department of Neurosurgery, Yonsei University, College of Medicine, Seoul, Korea.
2Department of Radiology, Yonsei University, College of Medicine, Seoul, Korea.
A new radiopharmaceutical, technetium-99m hexamethylpropyleneamine oxime(99mTc-HMPAO), has been reported to cross the blood-brain-barrier and to distribute in brain in proportion to regional blood flow. Measurement of cerebral blood flow with single photon emixxion computed tomography(SPECT) was performed using 99mTc-HMPO in 46 patients and clinical analysis was done. Decreased regional cerebral perfusion was observed in 41 cases. Moreover eight cases of them who had normal X-ray C-T scan revealed positive finding on SPECT. We porpose that 99mTc-HMPAO SPECT seems to be a useful diagnostic method for evaluation of ischemic cerebral lesions.
Key Words: 99mTc-HMPAO; SPECT; rCBF; Cerebrovascular disease
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