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Journal of Korean Neurosurgical Society 1990;19(7): 927-936.
Correlation between Changes of Cerebrospinal Lactate Level and Prognosis in Severely Head-Injured Patients.
Bum Dae Kim, Jang Ho Bae, Eun Sig Doh, Sam Kyu Ko, Oh Lyong Kim, Yong Chul Chi, Byung Yearn Choi, Soo Ho Cho
Department of Neurosurgery, College of Medicine, Yeungnam University, Taegu, Korea.
Cerebrospinal fluid lactate and intracranial pressure were measured in 24 severely head-injured patients with Glasgow coma scale below 8. Cerebral perfusion pressure, vital sign and CVP were also measured simultaneously. Severely head-injured patients revealed increased CSF lactate and intracranial pressure which have been significantly correlated with outcome. But changes of vital sign, cerebral perfusion pressure and CVP were not correlated with outcome. The elevation of intracranial pressure checked on arrival was statistically significant in correlation to outcome. And the elevation of CSF lactate were correlated with statistically significance in correlation with outcome and lactate level checked on time interval(arrival, 12hr, 24hr, 48hr after trauma). And so CSF lactate levels are statistically more significant than intracranial pressure in predicting prognosis. We will expect good prognosis in severely head-injured patient by reducing intracranial pressure and CSF lactate, oxygenation and increasing cerebral perfusion.
Key Words: Cerebrospinal fluid lactate; Intracranial pressure; Severely head-injured patients; Glasgow coma scale
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