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Journal of Korean Neurosurgical Society > Volume 20(1-3); 1991 > Article
Journal of Korean Neurosurgical Society 1991;20(1-3): 28-35.
Nimodipine Treatment after Aneurysmal Subarachnoid Hemorrhage and Operation.
Dae Hee Han, Young Seob Chung, Sun Ho Lee
Department of Neurosurgery, Seoul National University, College of Medicine, Seoul, Korea.
Fifty-one consecutive 186 patients with aneurysmal subarachnoid hemorrhage were treated from the day of admission with nimodipine which was given first as an IV infusion at 30ug/kg/hr for 1 week and then orally in a dose of 360mg/day for 2 weeks and compared with 135 patients which were treated without nimodipine for the past 2 years. A comparision based on clinical and radiological variables influencing both the coruse and the outcome of the disease showed no significant difference between the nimodipine treated group and the control group except the delayed timing of surgery in the control group. There was no significant difference in the outcome between the nimodipine treated patients and the patients treated without nimodipine, however in Hung & Hess grade IV patients nimodipine treatment was associated with a significantly better outcome. Nimodipine treatment reduced the occurrence of delayed ischemic deficts(DID) in grade III, IV patients. Significant improvement in the outcome occurred in the nimodipine treated patients with subarachnoid hemorrhage of large amount(Fisher classification III).
Key Words: Intracranial aneurysm; Subarachnoid hemorrhage; Nimodipine; Delayed ischemic deficits
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