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Journal of Korean Neurosurgical Society 1991;20(4): 184-192.
Estrogen and Progesterone receptors in Meningioma.
Yong Gu Chong, Ki Chan Lee, Hoon Kap Lee, Jeong Wha Chu, Yang Sok Chae
1Department of Neurosurgery, College of Medicine, Korea University, Seoul, Korea.
2Department of Pathology, College of Medicine, Korea University, Seoul, Korea.
We studied the status of estrogen(ER) and progesterone(PR) receptors in meningiomas removed from 32 patients, using immunoperoxidase(IP) assays. PR were detected in 72% of the cases & ER were detected in 31%. The possible correlation between age, sex, histological type, ploidy pattern and proliferation index values with steroid receptor activity were discussed. The date suggest that the majority of meningiomas contain high affinity receptors for progesterone, that estrogen receptors are present in only a few meningiomas.
Key Words: Immunoperoxidase assay; Estrogen receptor; Progesterone receptor; Meningiomas
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