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Journal of Korean Neurosurgical Society 1992;21(1): 58-65.
Correlation of Estrogen and Progesteron Receptor's Concentration with the Proliferative Potential of Human Brain Tumors.
K G Cho, S H Shin, S S Chung
1Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
2Department of Biochemistry, Christian Medical Research Center, Presbyterian Medical Center, Chonju, Korea.
Steroid receptors have been suggested to play an important role in the synthesis of DNA and the growth of cells. Authors have estimated the concentrations of estrogen and progesterone receptors using the ELISA method, and the proliferative potential using immunohistochemical stain with the monoclonal antibody to bromodeoxyuridine(BudR) in 46 human brain tumors(21 meningiomas, 12 astrocytomas, 7 schwannoma, 4 medullobastomas, and 2 pituitary tumors). In our studies, the concentration of receptors had no relationship with age and sex of patients, and tumor type, and the proliferative potential of the individual tumors.
Key Words: Steroid receptors; Proliferative potential; Bromodeoxyuridine(BudR); Brain tumor
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