|
|
|
Journal of Korean Neurosurgical Society 1993;22(5): 659-665. |
| An Integrated Logistic Formula for Dose Prescription in Radiosurgery. |
| Yong Gou Park, Sang Sup Chung, Jin Woo Chang, Jun Cho, Gi Hong Kim |
| Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea. |
|
|
|
|
|
| ABSTRACT |
|
Radiation necrosis is the main obstacle for radiosurgery delivering high dose ionizing radiation inhomogeneously into small field of lesion with spatial accuracy. The complication probability is closely related to dose-volume effect. To reduce the complication rate, the optimum dose should e prescribed for the isodose curve enclosing the target lesion according to the lesion volume and isodose fall-off. However, the shape, volume and isodose fall-off of the lesions are different from each other. To choose the optimum doses for radiosurgery in each case, it is necessary to have a reasonable model for predicting dose-volume effects. Flickinger developed an integrated logistic formula using normalized total dose(NTD) as a reasonable model to predict complications from gamma knife radiosurgery. The authors developed a computer program to calculate the risk probability using that formula. As previously emphasized, the risk probability derived from the formula is useful and indispensable as a guidance to dose prescription in gamma knife surgery. |
| Key Words:
Gamma knife; Radiosurgery; Integrated loistic formula; Radiation necrosis; Dose-volume effect |
|
|
|
Full text via DOI 
Download Citation 
