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Journal of Korean Neurosurgical Society 1993;22(6): 770-778.
A Case of Gonadotropin-Producing Pituitary Adenoma.
Sang Don Lee, Young Soo Ha, Chong Oon Park, Young Kim, Kweon Byeong Chae, Joon Mee Kim
1Department of Neurosurgery, College of Medicine, Inha University, Inchon, Korea.
2Department of Anatomical Pathology, College of Medicine, Inha University, Inchon, Korea.
ABSTRACT
A 58-year-old male with a pituitary adenoma was investigated and demonstrated to have hypersecretion of both gonadotropins in the basal state. Presenting symptoms included visual disturbance, headache, loss of libido, impotence, cold intolerance and urinary frequency. The patient denied alteration of hair distribution and did not disclosed the aral features, galactorrheaor gynecomastia. Dynamic assay with synthetic thyrotropin-releasing hormone and synthetic gonadotropin-releasing hormone result in increase of serum luteinizing hormone(LH) and follicle stimulating hormone(FSH). Immunochemically, tumor cell revealed positive reaction for chromogranin and FSH, but negative for LH. Electron microscopic examination using paraffin embedded block was failed to demonstrate classic neurosecretory granule, but some electron dense granules were found in the cytoplasm. Gonadotropin-producing pituitary adenomas are rare, but have been diagnosed more frequently as radiographic techniques and biochemical assays have improved. A review of the literatures documents pituitary tumor secreting both FSH and LH in the basal state and we report a case of gonadotropin-producing pituitary adenoma.
Key Words: Pituitary adenoma; Gonadotropin hypersecretion
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