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Journal of Korean Neurosurgical Society 1993;22(8): 891-897.
A Clinical Analysis of 20 Cases of Pineal Region Tumors.
Sung Jo Hong, Hyung Shik Shin, Min Sung Lee, Jae Goon Moon, Yoon Mo Kim
Department of Neurosurgery, Capital Armed Forces General Hospital, Seoul, Korea.
ABSTRACT
A retrospective analysis was made of 20 patients with pineal region tumors who were treated at the Department of Neurosurgery, Capital Armed Forces General Hospital between May of 1987 and March of 1993. We performed ventriculo-peritoneal shunt in 17 patients with obstructive hydrocephalus. Tissue diagnosis was obtained in 7 patients before irradiation and 13 patients underwent irradiation without histological diagnosis. Among 7 biopsy-proven cases, 5 were germinoma, one was mixed germ cell tumor and another one was astrocytoma. The response to irradiation and tumor marker study revealed that 13 patients who did not have tissue diagnosis seemed to be germinomatous, non-germinomatous germ cell tumors and endodermal sinus tumor. So, the following results were obtained. 1) The patients were all young males. 2) The main presenting symptoms and signs were headache, vomiting and papilledema. 3) The tumors were mainly presented as a round well-enhancing masses with calcification. 4) Based on the classification of pineal tumor, germinoma was predominant tumor type. 5) The extrapineal metastasis was found in 5 cases(25.0%). 6) The tumor marker (alpha-FP or HCG) was positive in 5 cases(25.0%). 7) Germinoma showed excellent prognosis after the irradiation.
Key Words: Pineal region tumor; Germ cell tumor; Germinoma; Tumor marker; Radiotherapy
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