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Journal of Korean Neurosurgical Society > Volume 22(9); 1993 > Article
Journal of Korean Neurosurgical Society 1993;22(9): 947-952.
Experimental Study of the Effect of Nimodipine on CSF Formation.
Jun Hyeok Song, Youn Kwan Park, Heung Seob Chung, Jung Keun Suh, Hoon Kap Lee, Ki Chan Lee, Chung Wha Chu
Department of Neurosurgery, Korea University, Seoul, Korea.
The author has performed an experimental study in order to investigate the effect of nimodipine on the production of CSF in 12 cats. The cats were divided into 2 groups, one for nimodipine intravenous infusion and the other for its vehicle infusion group. Using ventriculo-cisternal perfusion method, nimodipine and its vehicle were examined for their effects on CSF formation rate respectively. Baseline CSF formation rate was 22.5+/-2.9 microliter/min(S.E.) and it gradually reduced to 17.0+/-3.4 microliter/min(S.E.) after final infusion of nimodipine at 60 microgram/kg/min. Vehicle infusion revealed no significant change in CSF formation rate. Although the nimodipine insuion revealed declining tendency in CSF formation rate along with increment of nimodipine concentration, it was not statistically different from that of vehicle infusion group. Systolic blood pressure was significantly reduced after nimodipine infusion(133+/-31.8mmHg at baseline, 93.9+/-19.1mmHg at the end of the experiment) on oneway ANOVA test and it was significantly different from that in vehicle infusion group(p<0.01).
Key Words: Nimodipine; CSF formation; Ventriculo-cisternal perfusion
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