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Journal of Korean Neurosurgical Society > Volume 22(9); 1993 > Article
Journal of Korean Neurosurgical Society 1993;22(9): 983-989.
The Prognostic Factors in the Oligodendrogliomas.
Jang Chull Lee, Sun Hee Lee, Man Bin Yim, Sang Yeol Kim, Eun Ik Son, Dong Won Kim, In Hong Kim, Sang Pyo Kim
1Department of Neurosurgery, School of Medicine, Keimyung University, Taegu, Korea.
2Department of Pathology, School of Medicine, Keimyung University, Taegu, Korea.
ABSTRACT
In order to find out the prognostically significant factors in the oligodendrogliomas, we investigated the relationship between the clinical and histopathological characteristics and the mean survival time after surgery in 21 cases of oligodendrogliomas which were managed surgically and confirmed pathologically during the 12-year period. The survival analyses were performed on eight possible prognostic factors including age, duration of symptoms, Kernohan grade, mitosis, pleomorphism, endothelial proliferation, cell density, and gliofibrillary oligodendrocyte(GFOC) which was detected by immunohistochemical method. The results revealed that the tumor grade as classified by the Kernohan, cell density and the GFOC in Kernohan grade I & Ii had a prognostic significancy in order of decreasing importance. The best prognosis of the cases was found in the absence of GFOC in Kernohan grade I & II. The 2-year and 5-year survival rates after surgery were estimated as 62% and 42%, respectively.
Key Words: Gliofibrillary oligodendrocyte(GFOC); Immunohistochemistry; Kernohan grade; Oligodendroglioma; Prognostic factor
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