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Journal of Korean Neurosurgical Society 1993;22(12): 1295-1303.
A Comparative Study of BudR, AgNOR's, and PCNA in Benign and Malignant Astrocytoma.
W C Lee, M S Shin, N Jung, S K Huh, H K Lee
1Department of Neurosurgery, Presbyterian Medical Center, Jeonju, Korea.
2Department of Pathology, Presbyterian Medical Center, Jeonju, Korea.
In 14 cases of astocytoma, we performed a comparative study of BudR, AgNOR's, and PCNA with histopathology. Fourteen astrocytomas were classified histopathologically into low grade, anaplastic, and G.M.(glioblastoma multiforme) groups. These comprised 3 G.M., 5 anaplastic astrocytomas, and 6 low grade astrocytomas. The mean BudR-LI(Labeling Index) was statistically different(P<0.005) between G.M.(10.4), anaplastic astrocytoma(3.6), and low grade astrocytoma(1.3). On the basis of correlation between BudR-LI and histopathology which was reported in 1989 at PMC, we examined the relationship between BudR-LI and AgNOR's count, and between BudR-LI and PCNA-LI, Both AgNOR's count and PCNA-LI did not correlate with BudR-LI, and also not with histopathology. This study indicates that, at present, for prognosis and differentiation between malignant and benign astrocytoma, histopathology and BudR-LI are important.
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