| Home | E-Submission | Sitemap | Editorial Office |  
Journal of Korean Neurosurgical Society 1994;23(5): 548-552.
Technetium-99m-MIBI SPECT in Intracranial Lesions.
Sung Chan Park, Yong Kil Hong, Woo Hyun Sung, Kyung Jin Lee, Young Sup Park, Min Woo Baik, Joon Ki Kang, Chang Rak Choi
Department of Neurosurgery, Catholic University Medical College, Seoul, Korea.
Thallium(T1) has recently been used as a pharmaceutical for tumor imaging and staging. The aim of this study was to evaluate the clinical significance of the T1 analogue, 99m-Tc-MIBI(methoxyisobutylisonitrile), for imaging of intracranial lesions. The advantages of MIBI were though to be a lower radiation exposure and better image quality than with T1. 99m-Tc-MIBI SPECT studies were done in 30 patients with brain tumors(14 astrocytomas, 7 meningiomas, 2 hemangioblastomas, 2 craniopharyngiomas, 1 ependymoma, 4 metastatic tumors) and in twelve patients with non-tumorous lesions(2 abscesses, 2 granulomas, 2 cysticercosis, 3 old intracerebral hemorrages, 1 infarction. 1 postoperative gliosis, 1 unknown pathology), and semiquantitative assessment of tracer uptake was made using a ratio of radioactivity for lesion to contralateral normal brain(Lesion/Contralateral normal brains ; L/C). Twenty six of thirty tumors showed high L/C ratios(>1.5) and another four tumors low L/C ratios(<1.5). Of 12 non-tumorous intracranial lesions, 11 showed little or no uptake, but one moderate uptake. In conclusion, it appears that brain tumors show more intense focal uptake than non-tumorous brain lesions. However, further studies would be warranted to evaluate the clinical significance of MIBI SPECT in tumor staging(grading) and in differentiating necrosis from tumor regrowth more clearly.
Key Words: Thallium; 99m Tc-MIBI SPECT; Brain tumor
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Related articles
Massive Gastrointestinal Bleeding Following Intracranial Lesion.  1982 September;11(3)
Stereotactic Biopsy in Intracranial Lesions.  1989 May;18(5)
Traumatic Intracranial Aneurysms.  1993 December;22(12)
Delayed Traumatic Intracranial Lesion.  1994 June;23(6)
Infectious Intracranial Aneurysms.  1997 July;26(7)
Editorial Office
1F, 18, Heolleung-ro 569-gil, Gangnam-gu, Seoul, Republic of Korea
TEL: +82-2-525-7552   FAX: +82-2-525-7554   E-mail: office@jkns.or.kr
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © Korean Neurosurgical Society.                 Developed in M2PI
Close layer