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Journal of Korean Neurosurgical Society 1994;23(9): 1047-1054.
The Correlation Between the Clinical and Pathological Findings of the Intracranial Ependymomas.
Hae Cheol Lee, Dong Won Kim, Kun Young Kwon, Jang Chull Lee, Eun Ik Son, Man Bin Yim, In Hong Kim
1Department of Neurosurgery, Keimyung University School of Medicine, Taegu, Korea.
2Department of Pathology, Keimyung University School of Medicine, Taegu, Korea.
The clinical and pathological features were analyzed for 11 cases with intracranial ependymoma treated surgically at the Keimyung University Dongsan Medical Center during the years 1987 to 1992. Tumor histology was reviewed individually and grouped into three categories(Categories I to III) according to the pathologic grade used by Nazar, et al. There were 2 cases(18%) with category I histology, 5(45%) with category II histology, and 4(36%) with category III histology. The high recurrent rate, short recurrent interval, high rate of cerebrospinal fluid seeding and poor outcome were noted in patients with category III histology. The authors also investigated the recurrent interval according to the degree of tumor resection. The mean recurrent interval after surgery was 12 months in cases of subtotal resection and 33 months in a case of total resection. Tumors resected subtotally showed response to radiation and chemotherapy. In conclusion, the pathologic grade and the degree of tumor resection were regarded as important prognostic factors after surgery. Aggressive surgery with chemotherapy or radiotherapy were required in the management of intracranial ependymoma.
Key Words: Ependymoma; Clinicopathlogic correlation; Pathologic grade; Prognosis
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