| Home | E-Submission | Sitemap | Editorial Office |  
Journal of Korean Neurosurgical Society 1995;24(6): 623-630.
Study on Contractile Responses Induced by Anoxia in Porcine Cerebral Artery.
Jun Seog Ko, Sam Suk Kang, Yung Hong Baik
1Department of Neurosurgery, Chonnam University Hospital & Medical School, Kwangju, Korea.
2Department of Pharmacology, Chonnam University Hospital & Medical School, Kwangju, .
This study was designed to observe anoxia-induced responses and to clarify their possible mechanisms in porcine basilar and circle of Willis arteries. Anoxia produced a transient vasoconstriction, which then recovered to the basal tension of a 3-5 min. later, and the reoxygenation that follows produced the biphasic(relaxation-contraction) response in the intact endothelial rings under resting tension. The anoxia-induced contraction was potentiated by pretreatment with KC1 and PGF2alpha. Reoxygenation produced only sustained relaxation. Removal of the endothelium and pretreatment with nimodipine or indomethacine markedly attenuated the anoxia-induced contractions. Anoxia transiently and significantly increased cyclic GMP contents in the endothelium-intact preparations, but did not affect them in the endothelium-removed ones. The above results suggest that anoxia-induced contraction is endothelium-dependent and is resultant to the release of a Prostaglandin-like substance(s) .
Key Words: Anoxia; Porcine cerebral arteries; Endothelium; Endothelium; Cyclic GMP; Prostaglandin
Editorial Office
1F, 18, Heolleung-ro 569-gil, Gangnam-gu, Seoul, Republic of Korea
TEL: +82-2-525-7552   FAX: +82-2-525-7554   E-mail: office@jkns.or.kr
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © Korean Neurosurgical Society.                 Developed in M2PI
Close layer