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Journal of Korean Neurosurgical Society > Volume 24(6); 1995 > Article
Journal of Korean Neurosurgical Society 1995;24(6): 623-630.
Study on Contractile Responses Induced by Anoxia in Porcine Cerebral Artery.
Jun Seog Ko, Sam Suk Kang, Yung Hong Baik
1Department of Neurosurgery, Chonnam University Hospital & Medical School, Kwangju, Korea.
2Department of Pharmacology, Chonnam University Hospital & Medical School, Kwangju, .
ABSTRACT
This study was designed to observe anoxia-induced responses and to clarify their possible mechanisms in porcine basilar and circle of Willis arteries. Anoxia produced a transient vasoconstriction, which then recovered to the basal tension of a 3-5 min. later, and the reoxygenation that follows produced the biphasic(relaxation-contraction) response in the intact endothelial rings under resting tension. The anoxia-induced contraction was potentiated by pretreatment with KC1 and PGF2alpha. Reoxygenation produced only sustained relaxation. Removal of the endothelium and pretreatment with nimodipine or indomethacine markedly attenuated the anoxia-induced contractions. Anoxia transiently and significantly increased cyclic GMP contents in the endothelium-intact preparations, but did not affect them in the endothelium-removed ones. The above results suggest that anoxia-induced contraction is endothelium-dependent and is resultant to the release of a Prostaglandin-like substance(s) .
Key Words: Anoxia; Porcine cerebral arteries; Endothelium; Endothelium; Cyclic GMP; Prostaglandin
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