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Journal of Korean Neurosurgical Society 1996;25(4): 695-700.
Clinical Analysis of Lymphocyte Population Changes in Severe Head Injured Patients Using Flow Cytometry.
Ho Suk Jang, Young Seok Park, Young Bae Lee, Kyu Chun Lee, Chan Jung, Jin Ho Mok
Department of Neurosurgery, Dong-guk Universty, Kyoung Ju, Korea.
Despite advancement in diagnosis and progress in the management of intracranial pressure, infection remains a common complication following severe head injury. This following study attempts to better define the cell mediated immunity that decreased immediately following severe head injury. Twenty-five patients admitted with severe head injury(mean Glasgow Coma Scale, 5.32) were studied at the emergency rooms. The control group consisted of 25 mildly head-injured patients requiring hospital observation. Phenotyping of peripheral blood lymphocytes(PBL), determined by flow cytometry using monoclonal antibodies to lymphocytes subpopulation and HLA-DR receptors, was performed immediately following head injury. When severely head-injured patients were compared with controls, it was observed that the total T-cell counts(p<0.01) were markedly decreased, whereas the NK cell counts(p<0.01) were found to be increased. Infection rate of the study group was 44% and the majority of infections occur within the first 10 days after sever head injury. The results of this study suggests that severely head-injured patients had a decreased T-cell population and subpopulation in lines with higher infection rate.
Key Words: Cell-mediated immunity; Head injury; T-cell; Infection
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