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Journal of Korean Neurosurgical Society > Volume 25(5); 1996 > Article
Journal of Korean Neurosurgical Society 1996;25(5): 992-995.
Antibiotic Concentrations of Cerebrospinal fluid in Patients with Various Amount of Extraventricular Drainage during Intraventricular Infusion.
Soo Han Yoon, Young Hwan Ahn, Young Min Ahn, Kyung Gi Cho
Department of Neurosurgery, Ajeu University Hospital, Suwon, Korea.
Phamacokinetic study of the antibiotic concentrations in the cerebrospinal fluid was done with high pressure liquid chromatography of CSF samples from twelve patients who had various amount of continuous extra-ventricular drainage during antibiotic administration. Five patients with large amount(over 150cc/day) of drainage had decreased CSF antibiotic concentrations dramatically below the effective concentration within 4 hours after intraventricular antibiotic administration, but six patients with small(less than 150cc/day) drainage maintained CSF antibiotic level above effective concentration even 24 hours after administration. In conclusion, repeated intraventricular administration of antibiotic is necessary to maintain the effective drug level in the patient with CSF drainage over 150cc/day.
Key Words: Intraventricular antibiotic administration; Phamacokinetics; High Pressure liquid chromatography; Extroventricular drainage
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