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Journal of Korean Neurosurgical Society > Volume 25(8); 1996 > Article
Journal of Korean Neurosurgical Society 1996;25(8): 1679-1685.
Pleomorphic Xanthoastrocytoma: Report of 2 Cases.
Han Sik Kim, Byung Kook Min, Jeong Taik Kwon, Young Beak Kim, Eon Sub Park, Kwan Park, Jong Sik Suk
1Department of Neurosurgery, College of Medicine, Chungang University, Seoul, Korea.
2Department of Pathology, College of Medicine, Chungang University, Seoul, Korea.
ABSTRACT
Pleomorphic xanthoastrocytoma is a recently characterized neoplasm with relatively favorable prognosis despite aggressive histological features. Two cases of pleomorphic xanthoastrocytoma involving the left temporal lobe are reported, both occurring in adolescents. The tumor is considered to arise from the subpial astrocytes of the superficial cortex. Electron microscopic examination and immunoperoxidase stains for glial fibrillary acidic protein(GFAP) are helpful in making a definitive histologic diagnosis. In contrast to malignant gliomas, pleomorphic xanthoastrocytoma does not appear to require aggressive postoperative radiation therapy or chemotherapy. Therefore, It is important to recognize and identify this type of glioma as a distinct entity.
Key Words: Pleomorphic xanthoastrocytoma; Favorable prognosis; Temporal lobe; GFAP
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