| Home | E-Submission | Sitemap | Editorial Office |  
top_img
Journal of Korean Neurosurgical Society 1997;26(1): 48-53.
Comparative Study of the Proliferating Cell Nuclear Antigen and Clinicopathological Features in Intracranial Meningiomas.
Choong Hyun Kim, Young Il Ha
1Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
2Department of Neurosurgery, Kangnam General Hospital, Public Corporation, Seoul, Korea.
ABSTRACT
The PC10, a monoclonal antibody(mAb) to proliferating cell nuclear antigen(PCNA), is known to show immunoreactivity in paraffin embedded tissue. The authors present the relation between PCNA expression and clinicopathological features such as patient's age and sex, tumor size and location, histological types, and recurrence in 18 intracranial meningiomas. PCNA scores were obtained by immunostaining of the paraffin embedded surgical specimens using a streptoavidin/peroxidase method with PC10 mAb, which recognized an epitope on the PCNA. Univariate analysis showed that high PC10 scores were associated with old age(>or=50 years old), male, recurrent tumor and meningothelial type. However, these high scores did not reach statistical significance(p>0.05). PC10 scores of basal meningioma tended to be higher than that of hemispheric meningioma(p<0.05). The staining intensity of PCNA was markedly increased in basal meningiomas. It is suggested that the proliferative potential is higher in basal meningiomas than in hemispheric meningiomas, however, the number of patients in this study is too small to draw a statistical conclusion.
Key Words: Meningioma; PCNA; Clinicopathological features
Editorial Office
1F, 18, Heolleung-ro 569-gil, Gangnam-gu, Seoul, Republic of Korea
TEL: +82-2-525-7552   FAX: +82-2-525-7554   E-mail: kns61@neurosurgery.or.kr
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © Korean Neurosurgical Society.                 Developed in M2PI
Close layer