| Home | E-Submission | Sitemap | Editorial Office |  
Journal of Korean Neurosurgical Society 1998;27(3): 357-362.
Prolactinoma: Surgical Treatment and Outcome.
Taek Hyun Kwon, Yong Gu Chung, Tai Hyoung Cho, Jung Yul Park, Youn Kwan Park, Heung Seob Chung, Ki Chan Lee, Hoon Kap Lee
Department of Neurosurgery, College of Medicine, Korea University, Seoul, Korea.
Thirty-seven patients with prolactinoma treated over a seven-year period were retrospectively reviewed. During the same period, a total of 104 patients with pituitary adenoma were treated at our hospital, and among them, prolactinoma was the most frequently occurring tumor(35.6%); it was followed by nonfunctional adenoma and growth hormone-secreting adenoma. A female preponderance was observed with a male to female ratio of 1:3 .1. Prolactinoma patients were diagnosed at a younger age than pituitary adenoma patients in general; it seemed that the typical symptoms of prolactin excess facilitated early diagnosis. Tumors were classified as microadenoma(n=13) or macroadenoma(n=24) according to the their largest diameter as seen on CT or MRI images. Clinical symptoms were related to mass effect(visual field defect, loss of visual acuity, headache) and/or hormone excess(amenorrhea, galactorrhea). Mean preoperative serum prolactin level was 1027.9ng/ml(range, 39-14945), and this fell to a postoperative mean of 767.8ng/ml(2-10202). In patients with a preoperative serum prolactin level below 200ng/ml, ameorrhea improved in 76.5% of cases and serum prolactin level normalized in 73.7%, but in cases where this level was over 200ng/ml, amenorrhea improved in only 30% of cases and serum prolactin level returned to normal in only 22.2%. It appears that surgical outcome was mostly influenced by the preoperative serum prolactin level.
Key Words: Prolactinoma; Serum prolactin level
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Related articles
Surgical Treatment of Spasmodic Torticollis.  1972 October;1(1)
Microsurgical Treatment of Hemifacial Spasm.  1978 December;7(2)
Surgical Treatment of Intracranial Arachnoid Cyst.  1981 September;10(2)
Surgical Treatment of Craniosynostosis.  1983 December;12(4)
Surgical Treatment of Pontine Hematoma.  1983 December;12(4)
Editorial Office
1F, 18, Heolleung-ro 569-gil, Gangnam-gu, Seoul, Republic of Korea
TEL: +82-2-525-7552   FAX: +82-2-525-7554   E-mail: office@jkns.or.kr
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © Korean Neurosurgical Society.                 Developed in M2PI
Close layer