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Journal of Korean Neurosurgical Society 1998;27(3): 357-362. |
| Prolactinoma: Surgical Treatment and Outcome. |
| Taek Hyun Kwon, Yong Gu Chung, Tai Hyoung Cho, Jung Yul Park, Youn Kwan Park, Heung Seob Chung, Ki Chan Lee, Hoon Kap Lee |
| Department of Neurosurgery, College of Medicine, Korea University, Seoul, Korea. |
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| ABSTRACT |
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Thirty-seven patients with prolactinoma treated over a seven-year period were retrospectively reviewed. During the same period, a total of 104 patients with pituitary adenoma were treated at our hospital, and among them, prolactinoma was the most frequently occurring tumor(35.6%); it was followed by nonfunctional adenoma and growth hormone-secreting adenoma. A female preponderance was observed with a male to female ratio of 1:3 .1. Prolactinoma patients were diagnosed at a younger age than pituitary adenoma patients in general; it seemed that the typical symptoms of prolactin excess facilitated early diagnosis.
Tumors were classified as microadenoma(n=13) or macroadenoma(n=24) according to the their largest diameter as seen on CT or MRI images. Clinical symptoms were related to mass effect(visual field defect, loss of visual acuity, headache) and/or hormone excess(amenorrhea, galactorrhea).
Mean preoperative serum prolactin level was 1027.9ng/ml(range, 39-14945), and this fell to a postoperative mean of 767.8ng/ml(2-10202). In patients with a preoperative serum prolactin level below 200ng/ml, ameorrhea improved in 76.5% of cases and serum prolactin level normalized in 73.7%, but in cases where this level was over 200ng/ml, amenorrhea improved in only 30% of cases and serum prolactin level returned to normal in only 22.2%. It appears that surgical outcome was mostly influenced by the preoperative serum prolactin level. |
| Key Words:
Prolactinoma; Serum prolactin level |
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