| Home | E-Submission | Sitemap | Editorial Office |  
top_img
Journal of Korean Neurosurgical Society 1998;27(11): 1525-1532.
Immunohistochemical Analysis of Progesterone Receptor in Intracranial Meningiomas.
Jeong Hoon Kim, Jae Hee Suh, Byung Duk Kwun
1Department of Neurological Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
2Department of Diagnostic Pathology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
ABSTRACT
Meningiomas are common brain tumors that show a predilection for females and become more aggressive during pregnancy and menses. Clinical and epidemiological observations regarding meningiomas suggest a sex hormone dependency of these tumors. We reviewed the 47 intracranial meningiomas to examine the presence of the progesterone receptor(PR) by immunohistochemical methods and the relationships between the PR immunostaining status and other parameters, such as age, sex, tumor grade, mitotic index, and Ki-67 staining index. The PR staining status in these tumors was analyzed by immunohistochemistry on formalin-fixed paraffinembedded archival tissue sections utilizing the monoclonal antibody. The results are summarized as follows: 1) fifteen tumors(31.9%) tested were positive for the PR, 2) patients age and sex had no significant relationship with the PR positive rate of meningiomas(p=0.680, and 0.968, respectively), 3) although the positive immunostaining rate for the PR in benign meningiomas(37%) was higher than that in atypical and malignant meningiomas(25%), there was no statistically significant difference between these two groups(p=0.381), and 4) proliferative potentials such as the Ki-67 staining index and the mitotic index were not correlated with the PR staining status(p=0.4578 and 0.1981. respectively). We believe that further studies using large series of patients are needed to elucidate the role of the PR in meningiomas.
Key Words: Meningiomas; Sex hormone dependency; Progesterone receptor; Immunohistochemistry; Tumor parameter
TOOLS
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Share:      
METRICS
1,309
View
15
Download
Related articles
Clinical Analysis of Intracerebral Hematoma.  1975 October;4(2)
Clinical Analysis of 158 Surgically Treated Intracranial Aneurysms.  1976 October;5(2)
Clinical Analysis of 47 Cases of Intracranial Glioma.  1977 June;6(1)
Clinical Analysis of Traumatic Intracerebral Hematoma.  1978 December;7(2)
Clinical Analysis of Traumatic Intracranial Hemorrhage.  1979 September;8(2)
Editorial Office
1F, 18, Heolleung-ro 569-gil, Gangnam-gu, Seoul, Republic of Korea
TEL: +82-2-525-7552   FAX: +82-2-525-7554   E-mail: office@jkns.or.kr
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © Korean Neurosurgical Society.                 Developed in M2PI
Close layer