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Journal of Korean Neurosurgical Society 1999;28(8): 1208-1214. |
| Pathogenesis of Cerebral Vasospasm. |
| Chang Taek Moon |
| Department of Neurosurgery, College of Medicine, Konkuk University, Seoul, Korea. |
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| ABSTRACT |
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Although cerebral vasospasm is the greatest cause of morbidity and mortality in patient who survive the ictus of subarachnoid hemorrhage(SAH), the pathogenesis of vasospasm remains unclear. However, recent advances in the research of vasospasm suggest that decreased vasodilator function and/or increased vasoconstrictor function are basic changes of cerebral vasculature after SAH. So, the present review will focus on the roles of nitric oxide(NO), cGMP, potassium channel, endothelin(ET), and protein kinase C(PKC) as they relate to SAH. |
| Key Words:
Cerebral vasospasm; Subarachnoid hemorrhage; Nitric oxide; cGMP; Potassium channel; Endothelin; Protein kinase C |
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