Characteristics and Pathways of the Somatosensory Evoked Field Potentials in the Rat.

Shin, Hyun Chul; Park, Yong Gou; Lee, Bae Hwan; Ryou, Jae Wook; Zhao, Chun Zhi; Chung, Sang Sup

Original Article

Journal of Korean Neurosurgical Society 2001;30(7): 831-841.

Hyun Chul Shin, Yong Gou Park, Bae Hwan Lee, Jae Wook Ryou, Chun Zhi Zhao, Sang Sup Chung

¹Department of Neurosurgery, School of Medicine, Donga University, Pusan, Korea.
²Department of Neurosurgery, Medical Research Center, Brain Research Institute, Korea.
³Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT

OBJECTIVE
Somatosensory evoked potentials(SSEPs) have been used widely both experimentally and clinically to monitor the function of central nervous system and peripheral nervous system. Studies of SSEPs have reported the various recording techniques and patterns of SSEP. The previous SSEP studies used scalp recording electrodes, showed mean vector potentials which included relatively constant brainstem potentials(far-field potentials) and unstable thalamocortical pathway potentials(near-field potentials). Even in invasive SSEP recording methods, thalamocortical potentials were variable according to the kinds, depths, and distance of two electrodes. So they were regarded improper method for monitoring of upper level of brainstem. The present study was conducted to investigate the characteristics of somatosensory evoked field potentials(SSEFPs) of the cerebral cortex that evoked by hindlimb stimulation using ball electrode and the pathways of SSEFP by recording the potentials simultaneously in the cortex, VPL nucleus of thalamus, and nucleus gracilis.
METHODS
In the first experiment, a specially designed recording electrode was inserted into the cerebral cortex perpendicular to the cortical surface in order to recording the constant cortical field potentials and SSEFPs mapped from different areas of somatosensory cortex were analyzed. In the second experiment, SSEPs were recorded in the ipsilateral nucleus gracilis, the contralateral ventroposterolateral thalamic nucleus(VPL), and the cerebral cortex along the conduction pathway of somatosensory information.
RESULTS
In the first experiment, we could constantly obtain the SSEFPs in cerebral cortex following the transcutaneous electrical stimulation of the hind limb, and it revealed that the first large positive and following negative waves were largest at the 2mm posterior and 2mm lateral to the bregma in the contralateral somatosensory cortex. The second experiment showed that the SSEPs were conducted by way of posterior column somatosensory pathway and thalamocortical pathway and that specific patterns of the SSEPs were recorded from the nucleus gracilis, VPL, and cerebral cortex.
CONCLUSION
The specially designed recording electrode was found to be very useful in recording the localized SSEFPs and the transcutaneous electrical stimulation using ball electrode was effective in evoking SSEPs. The characteristic shapes, latencies, and conduction velocities of each potentials are expected to be used the fundamental data for the future study of brain functions, including the hydrocephalus model, middle cerebral artery ischemia model, and so forth.

Key Words: Somatosensory evoked potential; Cortex; Thalamus; Nucleus gracilis; Pathway