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Journal of Korean Neurosurgical Society > Volume 32(4); 2002 > Article
Journal of Korean Neurosurgical Society 2002;32(4): 307-311.
Surgical Outcome of Pituitary Prolactinomas.
Tae Young Jung, Jae Hyoo Kim, In Young Kim, Tae Sun Kim, Shin Jung, Soo Han Kim
Department of Neurosurgery, Chonnam University Hospital & Medical School, Gwangju, Korea.
The purpose of this study is to analyse the surgical outcome of prolactinoma and to evaluate the treatment modality.
Author has reviewed retrospectively the results of transsphenoidal microsurgical management in 26 patients with prolactin-secreting pituitary adenomas between 1995 and 2000. The patients were divided into three groups based on their preoperative serum prolactin levels:below 200ng/ml(Group A):over 200 to 500ng/ml(Group B):over 500(Group C).
During the same period, a total of 120 patients with pituitary adenoma were treated, and prolactinoma was the 21.6%. The mean age was 32.3+/-9.1 years and sex ratio(male-to-female ratio) was 1:5.5. The common clinical manifestations were amenorrhea, galactorrhea, headache, visual field defect and loss of visual acuity. Mean preoperative serum prolactin level was 1250.3ng/ml. The percentage of successful treatment(control rate) was 92.8% in Group A, 75% in Group B, and 0% in Group C.
The surgical control rates seem to justify surgery for these patients. For the most patients with serum prolactin levels over 500ng/ml, adjuvant treatment with bromocriptine after the surgery is recommended.
Key Words: Prolactinoma; Transsphenoidal approach
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