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Journal of Korean Neurosurgical Society > Volume 32(4); 2002 > Article
Journal of Korean Neurosurgical Society 2002;32(4): 307-311.
Surgical Outcome of Pituitary Prolactinomas.
Tae Young Jung, Jae Hyoo Kim, In Young Kim, Tae Sun Kim, Shin Jung, Soo Han Kim
Department of Neurosurgery, Chonnam University Hospital & Medical School, Gwangju, Korea.
ABSTRACT
OBJECTIVE:
The purpose of this study is to analyse the surgical outcome of prolactinoma and to evaluate the treatment modality.
METHODS:
Author has reviewed retrospectively the results of transsphenoidal microsurgical management in 26 patients with prolactin-secreting pituitary adenomas between 1995 and 2000. The patients were divided into three groups based on their preoperative serum prolactin levels:below 200ng/ml(Group A):over 200 to 500ng/ml(Group B):over 500(Group C).
RESULTS:
During the same period, a total of 120 patients with pituitary adenoma were treated, and prolactinoma was the 21.6%. The mean age was 32.3+/-9.1 years and sex ratio(male-to-female ratio) was 1:5.5. The common clinical manifestations were amenorrhea, galactorrhea, headache, visual field defect and loss of visual acuity. Mean preoperative serum prolactin level was 1250.3ng/ml. The percentage of successful treatment(control rate) was 92.8% in Group A, 75% in Group B, and 0% in Group C.
CONCLUSION:
The surgical control rates seem to justify surgery for these patients. For the most patients with serum prolactin levels over 500ng/ml, adjuvant treatment with bromocriptine after the surgery is recommended.
Key Words: Prolactinoma; Transsphenoidal approach
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