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Journal of Korean Neurosurgical Society > Volume 32(6); 2002 > Article
Journal of Korean Neurosurgical Society 2002;32(6): 543-547.
Vascular Endothelial Growth Factor-C Expression in Primary and Metastatic Brain Tumor.
Ji Hun Chung, Tae Sik Kong, Myoung Jae Kang, Dong Geun Lee, Myoung Ja Chung
1Department of Neurosurgery, Presbyterian Medical Center, Jeonju, Korea. mjchung@moak.chonbuk.ac.kr
2Department of Pathology, Chonbuk National University Medical School, Korea.
3Research Institute of Clinical Medicine, Jeonju, Korea.
ABSTRACT
OBJECTIVE:
Vascular endothelial growth factor(VEGF)-C is involved in lymphangiogenesis and spreading of cancer cells via lymphatic vessels. The aim of the present study is to investigate the relationship between the absence of cerebral lymphatic vessels and low metastatic rate of brain tumors.
METHODS:
Immunohistochemical stains were performed for VEGF-C and VEGF in surgically resected specimens from 57 patients with primary(38 cases, low grade : 10 cases, high grade : 28 cases) and metastatic(19 cases) brain tumor.
RESULTS:
The expression of VEGF-C was higher in metastatic carcinoma(68%) than in high-grade primary tumor(29%). There was no difference for VEGF expression between high grade brain tumor (71%) and metastatic carcinoma(58%).
CONCLUSION:
Low VEGF-C expression of primary brain tumors may play a role in low metastatic rate of brain tumors.
Key Words: Primary brain tumor; Metastatic brain tumor; VEGF-C; VEGF
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