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Journal of Korean Neurosurgical Society 2003;34(1): 65-67.
Lymphocytic Hypophysitis: Case Report.
Chun Sung Cho, Bong Jin Park, Young Joon Kim, Maeng Ki Cho
Department of Neurosurgery, College of Medicine, Dankook University, Cheonan, Korea. hyunsong@dankook.ac.kr
ABSTRACT
The authors report two cases of lymphocytic hypophsitis: a 38-year-old male patient with headache and diabetes insipidus and in a 64-year-old female patient with headache. Magnetic resonance(MR) image of the patients showed mass-like lesions in the hypophysis as well as loss of high signal on T1-weighted MR images. There was evidence of hypopituitarism. Both patients underwent transsphenoidal approaches for histological diagnosis, which was compatable with lymphocytic hypophysitis. When MR image reveals a characteristic pituitary in the hypophysis lesion with relevant clinical symptoms in a patient, one should include "lymphocytic hypophysitis" as one of the diagnostic possibilities, since the therapeutic options are different from those of pituitary tumors.
Key Words: Lymphocytic hypophysitis; Central diabetes insipidus; Neurohypophysis; Sellar MRI; Transsphenoidal approach
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