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Journal of Korean Neurosurgical Society > Volume 34(2); 2003 > Article
Journal of Korean Neurosurgical Society 2003;34(2): 153-155.
Secretory Meningioma with Elevated Serum Carcinoembryonic Antigen.
Jong Hee Chang, Jin Woo Chang, Yong Gou Park, Tai Seung Kim
1Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea. ygpark@yumc.yonsei.ac.kr
2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
3Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
A 57-year old woman is diagnosed with a cavernous sinus meningioma, which is accompanied by an elevated serum carcinoembryonic antigen (CEA). The pathological findings revealed a secretory meningioma containing numerous pseudopsammoma bodies that tested strongly periodic acid-Schiff positive. Secretory meningioma is a rare histological variant that is characterized by a unique epithelial differentiation of meningothelial cells resulting in the production of hyaline inclusions. Although the increased preoperative serum CEA level is not a confirmative tool for secretory meningioma, it appears to be a useful marker for post-treatment follow-up or for detecting a tumor recurrence.
Key Words: Brain tumor; Carcinoembryonic antigen; Pseudopsammoma body; Secretory meningioma; Skull base
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