Preventive Effect of Anti-adhesion Barrier Gel for Peridural Fibrosis in Rat Laminectomy Model.

Yoon, Do Heum; Kim, Keung Nyun; Shin, Dong Ah; Lee, Jong Eun; Lee, Jung Goen; Kim, Do Hoon

Original Article

Journal of Korean Neurosurgical Society 2003;34(5): 456-460.

Do Heum Yoon, Keung Nyun Kim, Dong Ah Shin, Jong Eun Lee, Jung Goen Lee, Do Hoon Kim

¹Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea. ydoheum@yumc.yonsei.ac.kr
²Institute for R & D, Amitie Co., LTD.
³Department of Organ Reconstruction, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.

ABSTRACT

OBJECTIVE
The authors compare peridural scar formation and adhesion with and without the use of Antiadhesion Barrier Gel(Adba) in an animal model of laminectomy. METHODS: Forty-five Sprague-Dawley rats underwent a two level lumbar laminectomy. The Adba was applied to randomly assigned 30 rats around the dura. Remaining 15 rats underwent same operation without the use of Adba. The rats were sacrificed 2, 4, 8 weeks after surgery by 15 numbers. A gross anatomic assessment of scar formation was done using microdissection by an observer blinded to treatment. Amount of scar formation and tenacity were compared between experimental and control group by a numerical rating system. The histological comparing was also performed. RESULTS: The amount of scar tissue and tenacity were reduced grossly and histologically at postoperative 2, 4, 8 weeks in animal model using Adba. Adba material was absorbed around 4 weeks of postoperative period in model. No special inflammatory reaction was observed, and the healing of wound was not affected by Adba. CONCLUSION: Adba significantly reduces the amount of scar formation and tenacity in rat laminectomy model without impacting the healing of operation wound and other complications.

Key Words: Adba(Anti-adhesion Barrier Gel); Scar formation; Adhesion; Laminectomy