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Journal of Korean Neurosurgical Society > Volume 35(1); 2004 > Article
Journal of Korean Neurosurgical Society 2004;35(1): 1-11.
Advances in Understanding the Molecular Biology of Brain Tumors.
John S Kuo, James T Rutka
The Arthur and Sonia Labatt Brain Tumour Research Centre and Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. james.rutka@sickkids.ca
Many advances have been made in understanding the molecular biology of brain tumors through progress in cell and developmental biology. The molecular characterization of rare genetic disorders and tumors shed light on several common tumorigenic mechanisms: mitogenic signaling, cell cycle control, development, and cell surface-cytoskeleton interactions. Discovery of many new molecular markers and the recent identification of brain tumor stem cells offer new directions in future research for tumor molecular diagnostics and therapies.
Key Words: Brain tumors; Molecular biology; Glioma; Medulloblastoma; Meningioma; Brain tumor stem cell
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