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Journal of Korean Neurosurgical Society 2004;35(1): 12-16.
Clinicopathological Analysis of Subependymal Giant Cell Astocytomas in Childhood.
Sang Hyuk Kim, Hyun Wook Lee, Hyung Jin Shin, Do Hyun Nam, Eun Sang Kim, Whan Eoh
Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. hjshin@smc.samsung.co.kr
The authors present an evaluation of clinical features and outcome of six children with subependymal giant cell astrocytoma(SEGA). METHODS: Between 1998 and 2002, six patients aged between 6 and 15 years were diagnosed as SEGA. Five out of six children had complex signs of tuberous sclerosis(TS) and remaining one child had intraventricular tumor without the evidence of TS. We uneventfully performed complete tumor resection in all patients via transcallosal approach. One child needed ventriculoperitoneal shunt due to sustained ventriculomegaly. RESULTS: All patients remained stable and did not deteriorate neurologically compared with preoperative state at a mean follow-up of 18 months.
Even though the SEGA has a benign biological behavior, surgery should be considered if there is a concurrent hydrocephalus, a sizeable tumor or interval volume increase of the tumor during the follow-up period.
Key Words: Subependymal giant cell astrocytoma; Tuberous sclerosis; Treatment outcome
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