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Journal of Korean Neurosurgical Society 2004;35(5): 465-471.
Bcl-2 and Bax Expression and Ki-67 Proliferative Index in Astrocytic Tumors: in Relation to Prognosis.
Sei Yoon Kim, Soon Hee Chung, Hun Joo Kim, Kum Whang, Young Pyo Han, Soon Ki Hong
1Department of Neurosurgery, Wonju College of Medicine, Yonsei University, Wonju, Korea.
2Department of Pathology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
We report a retrospective investigation of the prognostic value of bcl-2 and bax expression, and Ki-67 proliferative index in 42 astrocytic tumors. METHODS: We classified the astrocytic tumors and reviewed the clinical information and survival time. The sections were taken from surgically resected paraffin-embedded tissue and performed immunohistochemical stains for bcl-2, bax and Ki-67.
The immunohistochemical stain for bcl-2 revealed a positivity in only two(4.76%) among forty-two cases. The immunostain for bax was positive in 35 cases(83.3%). However, the correlation between bcl-2 & bax expression and age, sex, tumor location, size, and histologic grade was not found. By Kaplan-Meier analysis, bcl-2 & bax expression and survival time in astrocytic tumors was no significance in log rank test(p>0.05). There were prognostic values between Ki-67 LI and histologic grade and between Ki-67 LI and survival time, respectively(p<0.05). CONCLUSION: Bcl-2 and bax are not significant, whereas Ki-67 LI is suggested as a significant prognostic factor, associated with histologic grade and survival time of astrocytic tumors.
Key Words: Astrocytic tumor; Bcl-2; Bax; Ki-67; Prognostic factor
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