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Journal of Korean Neurosurgical Society 2004;35(5): 465-471. |
| Bcl-2 and Bax Expression and Ki-67 Proliferative Index in Astrocytic Tumors: in Relation to Prognosis. |
| Sei Yoon Kim, Soon Hee Chung, Hun Joo Kim, Kum Whang, Young Pyo Han, Soon Ki Hong |
1Department of Neurosurgery, Wonju College of Medicine, Yonsei University, Wonju, Korea.
2Department of Pathology, Wonju College of Medicine, Yonsei University, Wonju, Korea. |
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| ABSTRACT |
OBJECTIVE
We report a retrospective investigation of the prognostic value of bcl-2 and bax expression, and Ki-67 proliferative index in 42 astrocytic tumors. METHODS: We classified the astrocytic tumors and reviewed the clinical information and survival time. The sections were taken from surgically resected paraffin-embedded tissue and performed immunohistochemical stains for bcl-2, bax and Ki-67.
RESULTS
The immunohistochemical stain for bcl-2 revealed a positivity in only two(4.76%) among forty-two cases. The immunostain for bax was positive in 35 cases(83.3%).
However, the correlation between bcl-2 & bax expression and age, sex, tumor location, size, and histologic grade was not found. By Kaplan-Meier analysis, bcl-2 & bax expression and survival time in astrocytic tumors was no significance in log rank test(p>0.05). There were prognostic values between Ki-67 LI and histologic grade and between Ki-67 LI and survival time, respectively(p<0.05). CONCLUSION: Bcl-2 and bax are not significant, whereas Ki-67 LI is suggested as a significant prognostic factor, associated with histologic grade and survival time of astrocytic tumors. |
| Key Words:
Astrocytic tumor; Bcl-2; Bax; Ki-67; Prognostic factor |
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