Parietal Lobe Epilepsy: Surgical Treatment and Outcome.

Kim, Chi Heon; Chung, Chun Kee; Lee, Sang Kun; Lee, Yoon Kyung; Chi, Je G

Original Article

Journal of Korean Neurosurgical Society 2004;36(2): 93-101.

Chi Heon Kim, Chun Kee Chung, Sang Kun Lee, Yoon Kyung Lee, Je G Chi

¹Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea. chungc@snu.ac.kr
²Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.
³Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
⁴Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
⁵Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, Korea.

ABSTRACT

OBJECTIVE
Parietal lobe epilepsy(PLE) is neither common nor easily diagnosed because of its variable clinical features. To elucidate its characteristics and surgical outcome, the authors review their surgical experiences. METHODS: Between September 1994 and August 2001, 38 patients with parietal lobe epilepsy received surgical treatment at our Hospital. All patients underwent resection, mainly involving the parietal lobe. In most patients, preoperative evaluation included interictal and ictal electroencephalography, magnetic resonance image, positron emission tomography, and interictal and ictal single photon emission computed tomography. The male to female ratio was 23: 15. Age at surgery ranged from 4 to 38 years (median, 25). RESULTS: Preoperatively over 60% were considered not to be PLE, even though PLE was the most common (15/38, 39.8 %). The most common seizure type was complex partial seizure (26/38, 68.4%) rather than simple partial seizure (3/38, 7.9%). Invasive study was performed in 37 of the 38 patients. Monitoring duration was from 4 to 18 days (median, 8 days). Awake operations under regional anesthesia were performed in 20 patients (52.6%). Follow-up periods ranged from 14 to 81 months (mean, 50.7). Seizure disappeared in 15 (Engel's classification I, 39.5%), and rare seizure remained in 5 (Engel II, 13.2%). Thirteen patients showed a worthwhile improvement (Engel III, 34.2%) and 5 no worthwhile improvement (Engel IV, 13.2%). Pathologies were diverse, the most common being cortical dysplasia (94.3%). CONCLUSION: Since PLE is difficult to diagnose preoperatively, an invasive study covering the parietal lobe is mandatory, if PLE is suspected. Cortical dysplasia was the most common etiology, thus awake operation under regional anesthesia and intraoperative brain mapping is helpful during extensive resection in order to spare the eloquent cortex. Using this protocol, PLE can be controlled surgically with a satisfactory result and a reasonably low level of complications.

Key Words: Parietal lobe epilepsy