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Journal of Korean Neurosurgical Society > Volume 36(6); 2004 > Article
Journal of Korean Neurosurgical Society 2004;36(6): 493-495.
Posterior Leukoencephalopathy Syndrome Following Intravenous Chemotherapy for Medulloblastoma in a Child.
Sung Bum Ahn, Shin Hyuk Kang, Yong Gu Chung, Hoon Kap Lee
Department of Neurosurgery, College of Medicine, Korea University, Seoul, Korea. hermes23@medimail.co.kr
ABSTRACT
Posterior leukoencephalopathy syndrome(PLES) is a rare neurological complication which is associated with malignant hypertension, pre-eclampsia, and some drugs including immunosuppressive agents. A 9-year-old boy who had cerebellar medulloblastoma showed seizure on the seventeenth day after intravenous chemotherapy including ACNU and vincristine. Radiologic findings were consistent with those of PLES due to vasospasm. After hypertensive therapy, the symptoms were improved. We present a case of PLES with medulloblastoma which developed following chemotherapy with the regimen of medulloblastoma in a child.
Key Words: Posterior leukoencephalopathy; Chemotherapy; Medulloblastoma
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