| Home | E-Submission | Sitemap | Editorial Office |  
Journal of Korean Neurosurgical Society 2005;37(1): 25-28.
Strategy for Management of Giant Invasive Pituitary Adenoma.
Hee Seok Yang, Oh Lyong Kim, Min Soo Kim, Sang Woo Kim, Chul Hun Chang, Soo Ho Cho
Department of Neurosurgery, College of Medicine, Yeungnam University, Daegu, Korea. olkim@med.yu.ac.kr
Giant invasive pituitary adenoma looks histologically benign, but these tumors have an aggressive clinical course. The authors review 10 cases and discuss the results obtained and the strategy to use for the management of giant invasive pituitary adenoma. METHODS: Out of a series of 155 pituitary adenomas treated surgically between 1994 and 2002, ten patients with giant invasive pituitary adenoma were selected and their clinical problems, radiologic findings, extent and invasiveness, hormonal and histologic findings and surgical results were analyzed retrospectively. RESULTS: There were 4 male and 6 female patients, with an average age of 47 years and an average follow-up period of 42 months. The average size of tumor was 50.7mm. These tumors revealed severe invasions into surrounding structures. 8 patients underwent transsphenoidal approach(TSA) operations, 1 patient with transcranial operation and 1 patient with combined TSA and transcranial operation. In all cases, subtotal resection was performed. The histologic findings were 2 prolactinomas and 8 hormonal non-function adenomas. The therapies administered after surgical removal consisted of conventional fractionated radiotherapy (2 patients), treatment with dopamine agonists to control hyperprolactinemia (2 patients), and treatment with hormone replacement (2 patients). CONCLUSION: Giant invasive pituitary adenomas are characterized by different forms of expansion and invasiveness and variable clinical problems. Because of their aggressive expansion and invasiveness, there are many different strategies which can be considered for their management. The authors obtain good results by choosing conservative surgical removal and multidisciplinary treatments with serial radiological and hormonal follow-up.
Key Words: Giant invasive pituitary adenoma; Transsphenoidal surgery; Tumor invasion
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Related articles
Pharmacological Management of Germinal Matrix-Intraventricular Hemorrhage  2023 May;66(3)
Malignant Pituitary Adenoma.  1976 June;5(1)
A Case of Giant Intraventricular Meningioma.  1979 March;8(1)
A Case of Moya-moya Disease with Pituitary Adenoma.  1979 September;8(2)
Clinical Analysis of Functiononing Pituitary Adenoma.  1982 December;11(4)
Editorial Office
1F, 18, Heolleung-ro 569-gil, Gangnam-gu, Seoul, Republic of Korea
TEL: +82-2-525-7552   FAX: +82-2-525-7554   E-mail: office@jkns.or.kr
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © Korean Neurosurgical Society.                 Developed in M2PI
Close layer